There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 914 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 901 | - |
dc.citation.title | JOURNAL OF CELL BIOLOGY | - |
dc.citation.volume | 158 | - |
dc.contributor.author | Gruneberg, U | - |
dc.contributor.author | Glotzer, M | - |
dc.contributor.author | Gartner, A | - |
dc.contributor.author | Nigg, EA | - |
dc.date.accessioned | 2023-12-22T11:36:56Z | - |
dc.date.available | 2023-12-22T11:36:56Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 2002-09 | - |
dc.description.abstract | In all eukaryotic organisms, the physical separation of two nascent cells must be coordinated with chromosome segregation and mitotic exit. In Saccharomyces cerevisiae and Schizosaccharomyces pombe this coordination depends on a number of genes that cooperate in intricate regulatory pathways termed mitotic exit network and septum initiation network, respectively. Here we have explored the function of potentially homologous genes in a metazoan organism, Caenorhabditis elegans, using RNA-mediated interference. Of all the genes tested, only depletion of CeCDC-14, the C. elegans homologue of the budding yeast dual-specificity phosphatase Cdc14p (Clp1/Flp1p in fission yeast), caused embryonic lethality. We show that CeCDC-14 is required for cytokinesis but may be dispensable for progression of the early embryonic cell cycles. In response to depletion of CeCDC-14, embryos fail to establish a central spindle, and several proteins normally found at this structure are mislocalized. CeCDC-14 itself localizes to the central spindle in anaphase and to the midbody in telophase. It colocalizes with the mitotic kinesin ZEN-4, and the two proteins depend on each other for correct localization. These findings identify the CDC14 phosphatase as an important regulator of central spindle formation and cytokinesis in a metazoan organism. | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELL BIOLOGY, v.158, no.5, pp.901 - 914 | - |
dc.identifier.doi | 10.1083/jcb.200202054 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.scopusid | 2-s2.0-0037009021 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30920 | - |
dc.identifier.url | https://rupress.org/jcb/article/158/5/901/32809/The-CeCDC14-phosphatase-is-required-for | - |
dc.identifier.wosid | 000177843000008 | - |
dc.language | 영어 | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.title | The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | CDC14 | - |
dc.subject.keywordAuthor | cytokinesis | - |
dc.subject.keywordAuthor | central spindle | - |
dc.subject.keywordAuthor | ZEN-4 | - |
dc.subject.keywordAuthor | AIR-2 | - |
dc.subject.keywordPlus | HISTONE H3 PHOSPHORYLATION | - |
dc.subject.keywordPlus | CELL-CYCLE PROGRESSION | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | CHROMOSOME CONDENSATION | - |
dc.subject.keywordPlus | CENTRAL SPINDLE | - |
dc.subject.keywordPlus | FISSION YEAST | - |
dc.subject.keywordPlus | MITOTIC EXIT | - |
dc.subject.keywordPlus | PROTEIN PHOSPHATASE | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | AURORA-B | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.