Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.startPage | 14553 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 9 | - |
dc.contributor.author | Ahn, Chi Bum | - |
dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | Han, Dae Geun | - |
dc.contributor.author | Kang, Hyun-Wook | - |
dc.contributor.author | Lee, Sung-Ho | - |
dc.contributor.author | Lee, Jae-Ik | - |
dc.contributor.author | Son, Kuk Hui | - |
dc.contributor.author | Lee, Jin Woo | - |
dc.date.accessioned | 2023-12-21T18:38:44Z | - |
dc.date.available | 2023-12-21T18:38:44Z | - |
dc.date.created | 2019-10-25 | - |
dc.date.issued | 2019-10 | - |
dc.description.abstract | A migration of cancer is one of the most important factors affecting cancer therapy. Particularly, a cancer migration study in a microgravity environment has gained attention as a tool for developing cancer therapy. In this study, we evaluated the proliferation and migration of two types (adenocarcinoma A549, squamous cell carcinoma H1703) of non-small cell lung cancers (NSCLC) in a floating environment with microgravity. When we measured proliferation of two NSCLCs in the microgravity (MG) and ground-gravity (CONT), although initial cell adhesion in MG was low, a normalized proliferation rate of A549 in MG was higher than that in CONT. Wound healing results of A549 and H1703 showed rapid recovery in MG; particularly, the migration rate of A549 was faster than that of H1703 both the normal and low proliferating conditions. Gene expression results showed that the microgravity accelerated the migration of NSCLC. Both A549 and H1703 in MG highly expressed the migration-related genes MMP-2, MMP-9, TIMP-1, and TIMP-2 compared to CONT at 24 h. Furthermore, analysis of MMP-2 protein synthesis revealed weaker metastatic performance of H1703 than that of A549. Therefore, the simulated microgravity based cancer culture environment will be a potential for migration and metastasis studies of lung cancers. | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.9, pp.14553 | - |
dc.identifier.doi | 10.1038/s41598-019-50736-6 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.scopusid | 2-s2.0-85073102224 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30437 | - |
dc.identifier.url | https://www.nature.com/articles/s41598-019-50736-6 | - |
dc.identifier.wosid | 000489555200065 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Simulated microgravity with floating environment promotes migration of non-small cell lung cancers | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | MATRIX-METALLOPROTEINASE | - |
dc.subject.keywordPlus | TISSUE INHIBITORS | - |
dc.subject.keywordPlus | GELATINASE-A | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | MACHINE | - |
dc.subject.keywordPlus | ALTERS | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.