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DC Field | Value | Language |
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dc.citation.startPage | 3320 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 10 | - |
dc.contributor.author | Kang, Kyuho | - |
dc.contributor.author | Bachu, Mahesh | - |
dc.contributor.author | Park, Sung Ho | - |
dc.contributor.author | Kang, Keunsoo | - |
dc.contributor.author | Bae, Seyeon | - |
dc.contributor.author | Park-Min, Kyung-Hyun | - |
dc.contributor.author | Ivashkiv, Lionel B. | - |
dc.date.accessioned | 2023-12-21T18:56:25Z | - |
dc.date.available | 2023-12-21T18:56:25Z | - |
dc.date.created | 2019-11-14 | - |
dc.date.issued | 2019-07 | - |
dc.description.abstract | Activation of macrophage proinflammatory and antimicrobial phenotypes is regulated by IFN-γ and LPS via synergistic induction of canonical, inflammatory NF-κB target genes. However, whether IFN-γ negatively regulates components of the LPS response, and how this may affect macrophage activation, is still unclear. Here we use combined transcriptomic and epigenomic approaches to find that IFN-γ selectively abrogates LPS-induced feedback and alters macrophage metabolic pathways by suppressing TLR4-mediated gene activation. In contrast to superinduction of inflammatory genes via enhancers that bind IRF1 and STAT1, IFN-γ represses target enhancers that bind STAT3. TLR4-activated but IFN-γ-suppressed enhancers comprise two subsets discernable by differential regulation of histone acetylation and recruitment of STAT3, CDK8 and cohesin. Our findings thus show that IFN-γ suppresses feedback inhibitory and metabolic components of TLR responses to enhance macrophage activation; they also provide insights for IFN-γ-mediated selective inhibition of TLR4-induced transcription. Such inhibition can contribute to severe and sustained inflammatory responses. | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.10, pp.3320 | - |
dc.identifier.doi | 10.1038/s41467-019-11147-3 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.scopusid | 2-s2.0-85070672913 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30387 | - |
dc.identifier.url | https://www.nature.com/articles/s41467-019-11147-3 | - |
dc.identifier.wosid | 000477017600002 | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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