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Author

Kang, Sebyung
Protein Nanobio Lab
Research Interests
  • Protein engineering, Drug/diagnostics delivery nanoplatform, Protein-base vaccine delivery systems, Biosensor & imaging

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The ferritin superfamily: Supramolecular templates for materials synthesis

Cited 59 times inthomson ciCited 50 times inthomson ci
Title
The ferritin superfamily: Supramolecular templates for materials synthesis
Author
Uchida, MasakiKang, SebyungReichhardt, CourtneyHarlen, KevinDouglas, Trevor
Keywords
Bio-template; Biomimetic chemistry; Dps (DNA binding protein from nutrient starved cells); Ferritin; Janus particle; Multifunctionalities; Nanoparticle
Issue Date
201008
Publisher
ELSEVIER SCIENCE BV
Citation
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v.1800, no.8, pp.834 - 845
Abstract
Members of the ferritin superfamily are multi-subunit cage-like proteins with a hollow interior cavity. These proteins possess three distinct surfaces, i.e. interior and exterior surfaces of the cages and interface between subunits. The interior cavity provides a unique reaction environment in which the interior reaction is separated from the external environment. In biology the cavity is utilized for sequestration of irons and biomineralization as a mechanism to render Fe inert and sequester it from the external environment. Material scientists have been inspired by this system and exploited a range of ferritin superfamily proteins as supramolecular templates to encapsulate nanoparticles and/or as well-defined building blocks for fabrication of higher order assembly. Besides the interior cavity, the exterior surface of the protein cages can be modified without altering the interior characteristics. This allows us to deliver the protein cages to a targeted tissue in vivo or to achieve controlled assembly on a solid substrate to fabricate higher order structures. Furthermore, the interface between subunits is utilized for manipulating chimeric self-assembly of the protein cages and in the generation of symmetry-broken Janus particles. Utilizing these ideas, the ferritin superfamily has been exploited for development of a broad range of materials with applications from biomedicine to electronics.
URI
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DOI
http://dx.doi.org/10.1016/j.bbagen.2009.12.005
ISSN
0304-4165
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