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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Alterations in Cell Proliferation Related Gene Expressions in Gastric Cancer

Cited 12 times inthomson ciCited 10 times inthomson ci
Title
Alterations in Cell Proliferation Related Gene Expressions in Gastric Cancer
Author
Kim, KyungtaeChun, Kyung-HeeSuh, Pann-GhillKim, In-Hoo
Keywords
Cell cycle;  Helicobacter pylori;  MiRNA;  Oncogene;  Promoter methylation;  Tumor suppressor
Issue Date
2011
Publisher
BEGELL HOUSE INC
Citation
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, v.21, no.3, pp.237 - 254
Abstract
Gastric cancer remains the fourth most prevalent cancer and the second leading cause of cancer-related death in the world. The predominant form of gastric cancer is adenocarcinoma, which originates from glandular epithelium of the gastric mucosa. The major risk factors for gastric cancer include diet, individual genetic variation, and, most importantly, infection with Helicobacter pylori (H. pylori). Certain strains of H. pylori assisted by some of its virulence factors seem to play a critical role in gastric cancer development. Several of these H. pylori virulence factors, which influence cellular proliferation signaling, have been identified. In addition, changes in the expression of several cell proliferation regulating genes accompany or cause the progression of gastric cancer. These changes include modifications of cell cycle regulators, oncogene activation, tumor suppressor inactivation, and miRNA profile alterations. Many of these changes result from H. pylori infection, although their impact on the cellular proliferation system underlying gastric cancer development has not yet been fully elucidated. We review certain features of gastric cancer, the role of H. pylori infection in its etiology and pathogenesis, and gene expression changes during gastric carcinogenesis.
URI
http://scholarworks.unist.ac.kr/handle/201301/3032
DOI
http://dx.doi.org/10.1615/CritRevEukarGeneExpr.v21.i3.20
ISSN
1045-4403
Appears in Collections:
SLS_Journal Papers
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