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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells

Cited 8 times inthomson ciCited 6 times inthomson ci
Title
An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells
Author
Kim, Jung-MinChoi, Jin SeokKim, Yun-HeeJin, Seong HuiLim, SeyoungJang, Hyun-JunKim, Kyong-TaiRyu, Sung HoSuh, Pann-Ghill
Keywords
PROTEIN-KINASE-A; BONE-MASS; PARATHYROID-HORMONE; LEPTIN SECRETION; OVARIECTOMIZED MICE; GENE-TRANSCRIPTION; SIGNALING PATHWAY; INTERMITTENT PTH; IN-VITRO; OSTEOPOROSIS
Issue Date
201303
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF CELLULAR PHYSIOLOGY, v.228, no.3, pp.617 - 626
Abstract
Mesenchymal stem cells (MSCs) are multipotent adult stem cells capable of differentiating along the osteoblast, adipocyte, and chondrocyte lineages. Regulation of MSCs differentiation may be a useful tool for regenerative medicine and cell-based therapy. The discovery of small molecule that activates the osteogenic differentiation of MSCs could aid in the development of a new anabolic drug for osteoporosis treatment. We identified CW008, a derivative of pyrazolepyridine, that stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion. These results suggest that CW008 is an agonist of cAMP/PKA/CREB pathway in osteogenic differentiation and that application of CW008 may be useful for the treatment of bone-related diseases and for the study of bone biology.
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DOI
http://dx.doi.org/10.1002/jcp.24171
ISSN
0021-9541
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