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DC Field | Value | Language |
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dc.citation.endPage | 2796 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2791 | - |
dc.citation.title | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 40 | - |
dc.contributor.author | Do, Yoonkyung | - |
dc.contributor.author | Koh, Hyein | - |
dc.contributor.author | Park, Chae Gyu | - |
dc.contributor.author | Dudziak, Diana | - |
dc.contributor.author | Seo, Patrick | - |
dc.contributor.author | Mehandru, S. | - |
dc.contributor.author | Choi, Jae-Hoon | - |
dc.contributor.author | Cheong, Cheolho | - |
dc.contributor.author | Park, Steven | - |
dc.contributor.author | Perlin, David S. | - |
dc.contributor.author | Powell, Bradford S. | - |
dc.contributor.author | Steinman, Ralph M. | - |
dc.date.accessioned | 2023-12-22T06:43:14Z | - |
dc.date.available | 2023-12-22T06:43:14Z | - |
dc.date.created | 2013-06-07 | - |
dc.date.issued | 2010-10 | - |
dc.description.abstract | To help design needed new vaccines for pneumonic plague, we targeted the Yersinia pestis LcrV protein directly to CD8α + DEC-205 + or CD8α - DCIR2 + DC along with a clinically feasible adjuvant, poly IC. By studying Y. pestis in mice, we could evaluate the capacity of this targeting approach to protect against a human pathogen. The DEC-targeted LcrV induced polarized Th1 immunity, whereas DCIR2-targeted LcrV induced fewer CD4 + T cells secreting IFN-γ, but higher IL-4, IL-5, IL-10, and IL-13 production. DCIR-2 targeting elicited higher anti-LcrV Ab titers than DEC targeting, which were comparable to a protein vaccine given in alhydrogel adjuvant, but the latter did not induce detectable T-cell immunity. When DEC- and DCIR2-targeted and F1-V+ alhydrogel-vaccinated mice were challenged 6wk after vaccination with the virulent CO92 Y. pestis, the protection level and Ab titers induced by DCIR2 targeting were similar to those induced by F1-V protein with alhydrogel vaccination. Therefore, LcrV targeting to DC elicits combined humoral and cellular immunity, and for the first time with this approach, also induces protection in a mouse model for a human pathogen. | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF IMMUNOLOGY, v.40, no.10, pp.2791 - 2796 | - |
dc.identifier.doi | 10.1002/eji.201040511 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.scopusid | 2-s2.0-77957131592 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/2935 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77957131592 | - |
dc.identifier.wosid | 000283387500017 | - |
dc.language | 영어 | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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