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Author

Do, Yoonkyung
DC-based Immune System & Immunotherapy (DISNI) Lab
Research Interests
  • Study on various subsets of dendritic cells and their immunological functions

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Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague

Cited 14 times inthomson ciCited 13 times inthomson ci
Title
Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague
Author
Do, YoonkyungKoh, HyeinPark, Chae GyuDudziak, DianaSeo, PatrickMehandru, S.Choi, Jae-HoonCheong, CheolhoPark, StevenPerlin, David S.Powell, Bradford S.Steinman, Ralph M.
Keywords
CD205/DEC-205; DC; DCIR2; LcrV; Yersinia pestis
Issue Date
201010
Publisher
WILEY-V C H VERLAG GMBH
Citation
EUROPEAN JOURNAL OF IMMUNOLOGY, v.40, no.10, pp.2791 - 2796
Abstract
To help design needed new vaccines for pneumonic plague, we targeted the Yersinia pestis LcrV protein directly to CD8α + DEC-205 + or CD8α - DCIR2 + DC along with a clinically feasible adjuvant, poly IC. By studying Y. pestis in mice, we could evaluate the capacity of this targeting approach to protect against a human pathogen. The DEC-targeted LcrV induced polarized Th1 immunity, whereas DCIR2-targeted LcrV induced fewer CD4 + T cells secreting IFN-γ, but higher IL-4, IL-5, IL-10, and IL-13 production. DCIR-2 targeting elicited higher anti-LcrV Ab titers than DEC targeting, which were comparable to a protein vaccine given in alhydrogel adjuvant, but the latter did not induce detectable T-cell immunity. When DEC- and DCIR2-targeted and F1-V+ alhydrogel-vaccinated mice were challenged 6wk after vaccination with the virulent CO92 Y. pestis, the protection level and Ab titers induced by DCIR2 targeting were similar to those induced by F1-V protein with alhydrogel vaccination. Therefore, LcrV targeting to DC elicits combined humoral and cellular immunity, and for the first time with this approach, also induces protection in a mouse model for a human pathogen.
URI
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DOI
http://dx.doi.org/10.1002/eji.201040511
ISSN
0014-2980
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