Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells
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- Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells
- Lim, Seyoung; Jang, Hyun-Jun; Park, Eun Hee; Kim, Jung Kuk; Kim, Jung-Min; Kim, Eung-Kyun; Yea, Kyungmoo; Kim, Yun-Hee; Lee-Kwon, Whaseon; Ryu, Sung Ho; Suh, Pann-Ghill
- ADIPOGENESIS; MESENCHYMAL STEM CELLS; WEDELOLACTONE
- Issue Date
- JOURNAL OF CELLULAR BIOCHEMISTRY, v.113, no.11, pp.3436 - 3445
- Wedelolactone is an herbal medicine that is used to treat septic shock, hepatitis and venom poisoning. Although in differentiated and cancer cells, wedelolactone has been identified as anti-inflammatory, growth inhibitory, and pro-apoptotic, the effects of wedelolactone on stem cell differentiation remain largely unknown. Here, we report that wedelolactone inhibits the adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells (hAMSCs). Wedelolactone reduced the formation of lipid droplets and the expression of adipogenesis-related proteins, such as CCAAT enhancer-binding protein-a (C/EBP-a), peroxisome proliferator-activated receptor-? (PPAR-?), lipoprotein lipase (LPL), and adipocyte fatty acid-binding protein aP2 (aP2). Wedelolactone mediated this process by sustaining ERK activity. In addition, inhibition of ERK activity with PD98059 resulted in reversion of the wedelolactone-mediated inhibition of adipogenic differentiation. Taken together, these results indicate that wedelolactone inhibits adipogenic differentiation through ERK pathway and suggest a novel inhibitory effect of wedelolactone on adipogenic differentiation in hAMSCs.
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