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Park, Su-Moon
Electrochemistry Lab
Research Interests
  • Electrochemistry and spectroscopy of conducting polymers

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DNA Hybridization Sensors Based on Electrochemical Impedance Spectroscopy as a Detection Tool

Cited 48 times inthomson ciCited 47 times inthomson ci
Title
DNA Hybridization Sensors Based on Electrochemical Impedance Spectroscopy as a Detection Tool
Author
Park, Jin-YoungPark, Su-Moon
Keywords
Conducting polymers; DNA; EIS; Nanostructures; Self-assembled monolayers
Issue Date
200912
Publisher
MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
Citation
SENSORS, v.9, no.12, pp.9513 - 9532
Abstract
Recent advances in label free DNA hybridization sensors employing electrochemical impedance spectroscopy ( EIS) as a detection tool are reviewed. These sensors are based on the modulation of the blocking ability of an electrode modified with a probe DNA by an analyte, i.e., target DNA. The probe DNA is immobilized on a self-assembled monolayer, a conducting polymer film, or a layer of nanostructures on the electrode such that desired probe DNA would selectively hybridize with target DNA. The rate of charge transfer from the electrode thus modified to a redox indicator, e. g., [Fe(CN)(6)](3-/4-), which is measured by EIS in the form of charge transfer resistance (R(ct)), is modulated by whether or not, as well as how much, the intended target DNA is selectively hybridized. Efforts made to enhance the selectivity as well as the sensitivity of DNA sensors and to reduce the EIS measurement time are briefly described along with brief future perspectives in developing DNA sensors.
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DOI
http://dx.doi.org/10.3390/s91209513
ISSN
1424-8220
Appears in Collections:
SNS_Journal Papers
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