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Author

Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Ochratoxin A Inhibits Adipogenesis Through the Extracellular Signal-Related Kinases–Peroxisome Proliferator-Activated Receptor-g Pathway in Human Adipose Tissue-Derived Mesenchymal Stem Cells

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Title
Ochratoxin A Inhibits Adipogenesis Through the Extracellular Signal-Related Kinases–Peroxisome Proliferator-Activated Receptor-g Pathway in Human Adipose Tissue-Derived Mesenchymal Stem Cells
Author
Lim, SeyoungJang, Hyun-JunKim, Jung KukKim, Jung-MinPark, Eun HeeYang, Jun HyukKim, Yun-HeeYea, KyungmooRyu, Sung HoSuh, Pann-Ghill
Keywords
KIDNEY EPITHELIAL-CELLS; PROXIMAL TUBULAR CELLS; N-TERMINAL KINASE; HUMAN BONE-MARROW; PROTEIN-KINASE; PPAR-GAMMA; ADIPOCYTE DIFFERENTIATION; NEPHRITOGENIC OCHRATOXIN; INDUCED APOPTOSIS; IN-VITRO
Issue Date
201103
Publisher
MARY ANN LIEBERT INC
Citation
STEM CELLS AND DEVELOPMENT, v.20, no.3, pp.415 - 426
Abstract
Ochratoxin A (OTA) is a ubiquitous fungal metabolite with nephrotoxic, carcinogenic, and apoptotic potential. Although the toxic effects of OTA in various cell types are well characterized, it is not known whether OTA has an effect on stem cell differentiation. In this study, we demonstrate that OTA inhibits adipogenesis in human adipose tissue-derived mesenchymal stem cells, as indicated by decreased accumulation of intracellular lipid droplets. Further, OTA significantly reduces expression of adipocyte-specific markers, including peroxisome proliferator-activated receptor-gamma (PPAR-gamma), CCAAT enhancer binding protein-alpha (C/EBP-alpha), lipoprotein lipase (LPL), and adipocyte fatty acid-binding protein (aP2). At the molecular level, OTA phosphorylates PPAR-gamma 2 through extracellular signal-related kinase activation and inhibits PPAR-gamma activity. We also found that treatment with the mitogen-activated protein kinase kinase inhibitor, PD98059, significantly blocked the OTA-induced inhibition of adipogenesis. These results indicate that OTA suppresses adipogenesis in an extracellular signal-related kinase-dependent manner. Taken together, our results suggest a novel effect of OTA on adipocyte differentiation in human adipose tissue-derived mesenchymal stem cells and the possibility that OTA might affect the differentiation of other types of stem cells.
URI
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DOI
http://dx.doi.org/10.1089/scd.2010.0071
ISSN
1547-3287
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