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Author

Cho, Yoon-Kyoung
Integrated Nano-Biotech Lab (INBL)
Research Interests
  • Microfluidics, Lab-on-a-chip, personalized biomedical diagnostics, nanobioengineering

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Make Caffeine Visible: a Fluorescent Caffeine "Traffic Light" Detector

Cited 5 times inthomson ciCited 4 times inthomson ci
Title
Make Caffeine Visible: a Fluorescent Caffeine "Traffic Light" Detector
Author
Xu, WangKim, Tae-HyeongZhai, DuantingEr, Jun ChengZhang, LiyunKale, Anup AtulAgrawalla, Bikram KeshariCho, Yoon-KyoungChang, Young-Tae
Keywords
INFRARED-SPECTRUM; BODIPY LIBRARY; IMAGING PROBE; BEVERAGES; RECOGNITION; RISK; ADOLESCENTS; CONSUMPTION; NANOPROBES; CATECHINS
Issue Date
201307
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v.3, no., pp.1 - 7
Abstract
Caffeine has attracted abundant attention due to its extensive existence in beverages and medicines. However, to detect it sensitively and conveniently remains a challenge, especially in resource-limited regions. Here we report a novel aqueous phase fluorescent caffeine sensor named Caffeine Orange which exhibits 250-fold fluorescence enhancement upon caffeine activation and high selectivity. Nuclear magnetic resonance spectroscopy and Fourier transform infrared spectroscopy indicate that π-stacking and hydrogen-bonding contribute to their interactions while dynamic light scattering and transmission electron microscopy experiments demonstrate the change of Caffeine Orange ambient environment induces its fluorescence emission. To utilize this probe in real life, we developed a non-toxic caffeine detection kit and tested it for caffeine quantification in various beverages. Naked-eye sensing of various caffeine concentrations was possible based on color changes upon irradiation with a laser pointer. Lastly, we performed the whole system on a microfluidic device to make caffeine detection quick, sensitive and automated.
URI
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DOI
http://dx.doi.org/10.1038/srep02255
ISSN
2045-2322
Appears in Collections:
SLS_Journal Papers
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