Infrared controlled waxes for liquid handling and storage on a CD-microfluidic platform
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- Infrared controlled waxes for liquid handling and storage on a CD-microfluidic platform
- Abi-Samra, Kameel; Hanson, Ryan; Madou, Marc; Gorkin, Robert A., III
- WHOLE-BLOOD; CENTRIFUGAL; DISK; VALVES
- Issue Date
- ROYAL SOC CHEMISTRY
- LAB ON A CHIP, v.11, no.4, pp.723 - 726
- A novel active valving technique, whereby paraffin wax plugs in microchannels on a centrifugal microfluidic platform are actuated using focused infrared (IR) radiation is demonstrated in this report. Microchannels were simultaneously or sequentially opened using a stationary IR source by forming wax plugs with similar or differing melting points. The presented wax plugs offer key advantages over current active valving techniques, including a less involved fabrication procedure, a simpler actuation process, and the ability to multiplex experiment with active valves. In addition, a new technique for automated liquid reagent storage and release on the microfluidic disc platform, based on the formation and removal of a wax layer, is demonstrated. Overall, the techniques presented in this report offer novel methods for liquid handling, separation, and storage on the centrifugal microfluidic disc platform.
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