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Madou, Mark
BIO-MEMS Lab
Research Interests
  • Medical Diagnostics

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Infrared controlled waxes for liquid handling and storage on a CD-microfluidic platform

Cited 27 times inthomson ciCited 28 times inthomson ci
Title
Infrared controlled waxes for liquid handling and storage on a CD-microfluidic platform
Author
Abi-Samra, KameelHanson, RyanMadou, MarcGorkin, Robert A., III
Keywords
WHOLE-BLOOD; CENTRIFUGAL; DISK; VALVES
Issue Date
201102
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.11, no.4, pp.723 - 726
Abstract
A novel active valving technique, whereby paraffin wax plugs in microchannels on a centrifugal microfluidic platform are actuated using focused infrared (IR) radiation is demonstrated in this report. Microchannels were simultaneously or sequentially opened using a stationary IR source by forming wax plugs with similar or differing melting points. The presented wax plugs offer key advantages over current active valving techniques, including a less involved fabrication procedure, a simpler actuation process, and the ability to multiplex experiment with active valves. In addition, a new technique for automated liquid reagent storage and release on the microfluidic disc platform, based on the formation and removal of a wax layer, is demonstrated. Overall, the techniques presented in this report offer novel methods for liquid handling, separation, and storage on the centrifugal microfluidic disc platform.
URI
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DOI
http://dx.doi.org/10.1039/c0lc00160k
ISSN
1473-0197
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