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| DC Field | Value | Language |
|---|---|---|
| dc.citation.endPage | 3390 | - |
| dc.citation.number | 8 | - |
| dc.citation.startPage | 3386 | - |
| dc.citation.title | ACS CHEMICAL NEUROSCIENCE | - |
| dc.citation.volume | 10 | - |
| dc.contributor.author | Nam, Geewoo | - |
| dc.contributor.author | Ji, Yonghwan | - |
| dc.contributor.author | Lee, Hyuck Jin | - |
| dc.contributor.author | Kang, Juhye | - |
| dc.contributor.author | Yi, Yelim | - |
| dc.contributor.author | Kim, Mingeun | - |
| dc.contributor.author | Lin, Yuxi | - |
| dc.contributor.author | Lee, Young-Ho | - |
| dc.contributor.author | Lim, Mi Hee | - |
| dc.date.accessioned | 2023-12-21T18:48:52Z | - |
| dc.date.available | 2023-12-21T18:48:52Z | - |
| dc.date.created | 2019-09-19 | - |
| dc.date.issued | 2019-08 | - |
| dc.description.abstract | We report orobol as a multifunctional isoflavone with the ability to (i) modulate the aggregation pathways of both metal-free and metal-bound amyloid-beta, (ii) interact with metal ions, (iii) scavenge free radicals, and (iv) inhibit the activity of acetylcholinesterase. Such a framework with multifunctionality could be useful for developing chemical reagents to advance our understanding of multifaceted pathologies of neurodegenerative disorders, including Alzheimer's disease. | - |
| dc.identifier.bibliographicCitation | ACS CHEMICAL NEUROSCIENCE, v.10, no.8, pp.3386 - 3390 | - |
| dc.identifier.doi | 10.1021/acschemneuro.9b00232 | - |
| dc.identifier.issn | 1948-7193 | - |
| dc.identifier.scopusid | 2-s2.0-85068166172 | - |
| dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/27528 | - |
| dc.identifier.url | https://pubs.acs.org/doi/10.1021/acschemneuro.9b00232 | - |
| dc.identifier.wosid | 000482546100010 | - |
| dc.language | 영어 | - |
| dc.publisher | AMER CHEMICAL SOC | - |
| dc.title | Orobol: An Isoflavone Exhibiting Regulatory Multifunctionality against Four Pathological Features of Alzheimer's Disease | - |
| dc.type | Article | - |
| dc.description.isOpenAccess | FALSE | - |
| dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Chemistry, Medicinal; Neurosciences | - |
| dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Neurosciences & Neurology | - |
| dc.type.docType | Article | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.subject.keywordAuthor | Multifunctionality | - |
| dc.subject.keywordAuthor | flavonoid | - |
| dc.subject.keywordAuthor | amyloid-beta | - |
| dc.subject.keywordAuthor | metal-amyloid-beta | - |
| dc.subject.keywordAuthor | free radicals | - |
| dc.subject.keywordAuthor | acetylcholinesterase | - |
| dc.subject.keywordPlus | ACETYLCHOLINESTERASE | - |
| dc.subject.keywordPlus | INHIBITION | - |
| dc.subject.keywordPlus | PEPTIDE | - |
| dc.subject.keywordPlus | FIBRILLATION | - |
| dc.subject.keywordPlus | DEGRADATION | - |
| dc.subject.keywordPlus | OXIDATION | - |
| dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY RELATIONSHIPS | - |
| dc.subject.keywordPlus | AMYLOID-BETA | - |
| dc.subject.keywordPlus | METAL-FREE | - |
| dc.subject.keywordPlus | FLAVONOIDS | - |
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