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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 159 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 144 | - |
dc.citation.title | CELL SYSTEMS | - |
dc.citation.volume | 3 | - |
dc.contributor.author | Narayan, Vikram | - |
dc.contributor.author | Ly, Tony | - |
dc.contributor.author | Pourkarimi, Ehsan | - |
dc.contributor.author | Murillo, Alejandro Brenes | - |
dc.contributor.author | Gartner, Anton | - |
dc.contributor.author | Lamond, Angus I. | - |
dc.contributor.author | Kenyon, Cynthia | - |
dc.date.accessioned | 2023-12-21T23:16:03Z | - |
dc.date.available | 2023-12-21T23:16:03Z | - |
dc.date.created | 2019-09-10 | - |
dc.date.issued | 2016-08 | - |
dc.description.abstract | Effective network analysis of protein data requires high-quality proteomic datasets. Here, we report a near doubling in coverage of the C. elegans adult proteome, identifying > 11,000 proteins in total with similar to 9,400 proteins reproducibly detected in three biological replicates. Using quantitative mass spectrometry, we identify proteins whose abundances vary with age, revealing a concerted downregulation of proteins involved in specific metabolic pathways and upregulation of cellular stress responses with advancing age. Among these are similar to 30 peroxisomal proteins, including the PRX-5/PEX5 import protein. Functional experiments confirm that protein import into the peroxisome is compromised in vivo in old animals. We also studied the behavior of the set of age-variant proteins in chronologically age-matched, long-lived daf-2 insulin/IGF-1-pathway mutants. Unexpectedly, the levels of many of these age-variant proteins did not scale with extended lifespan. This indicates that, despite their youthful appearance and extended lifespans, not all aspects of aging are reset in these long-lived mutants. | - |
dc.identifier.bibliographicCitation | CELL SYSTEMS, v.3, no.2, pp.144 - 159 | - |
dc.identifier.doi | 10.1016/j.cels.2016.06.011 | - |
dc.identifier.issn | 2405-4712 | - |
dc.identifier.scopusid | 2-s2.0-85002926411 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/27437 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S2405471216302162?via%3Dihub | - |
dc.identifier.wosid | 000395773300008 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Deep Proteome Analysis Identifies Age-Related Processes in C. elegans | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | LIFE-SPAN REGULATION | - |
dc.subject.keywordPlus | HEAT-SHOCK FACTOR | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | GENETICS | - |
dc.subject.keywordPlus | MASS | - |
dc.subject.keywordPlus | INTERFERENCE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | KNOWLEDGE | - |
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