Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.number | 7 | - |
dc.citation.startPage | 301 | - |
dc.citation.title | PHARMACEUTICS | - |
dc.citation.volume | 11 | - |
dc.contributor.author | Kim, Kibeom | - |
dc.contributor.author | Choi, Huyeon | - |
dc.contributor.author | Choi, Eun Seong | - |
dc.contributor.author | Park, Myoung-Hwan | - |
dc.contributor.author | Ryu, Ja-Hyoung | - |
dc.date.accessioned | 2023-12-21T19:01:02Z | - |
dc.date.available | 2023-12-21T19:01:02Z | - |
dc.date.created | 2019-07-26 | - |
dc.date.issued | 2019-07 | - |
dc.description.abstract | Hyaluronic acid (HA) has been widely investigated in cancer therapy due to its excellent characteristics. HA, which is a linear anionic polymer, has biocompatibility, biodegradability, non-immunogenicity, non-inflammatory, and non-toxicity properties. Various HA nanomedicines (i.e., micelles, nanogels, and nanoparticles) can be prepared easily using assembly and modification of its functional groups such as carboxy, hydroxy and N-acetyl groups. Nanometer-sized HA nanomedicines can selectively deliver drugs or other molecules into tumor sites via their enhanced permeability and retention (EPR) effect. In addition, HA can interact with overexpressed receptors in cancer cells such as cluster determinant 44 (CD44) and receptor for HA-mediated motility (RHAMM) and be degraded by a family of enzymes called hyaluronidase (HAdase) to release drugs or molecules. By interaction with receptors or degradation by enzymes inside cancer cells, HA nanomedicines allow enhanced targeting cancer therapy. In this article, recent studies about HA nanomedicines in drug delivery systems, photothermal therapy, photodynamic therapy, diagnostics (because of the high biocompatibility), colloidal stability, and cancer targeting are reviewed for strategies using micelles, nanogels, and inorganic nanoparticles. | - |
dc.identifier.bibliographicCitation | PHARMACEUTICS, v.11, no.7, pp.301 | - |
dc.identifier.doi | 10.3390/pharmaceutics11070301 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.scopusid | 2-s2.0-85070959087 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/27191 | - |
dc.identifier.url | https://www.mdpi.com/1999-4923/11/7/301 | - |
dc.identifier.wosid | 000478995100005 | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Hyaluronic Acid-Coated Nanomedicine for Targeted Cancer Therapy | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.type.docType | Review | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | silica nanoparticle | - |
dc.subject.keywordAuthor | gold nanoparticle | - |
dc.subject.keywordAuthor | metal organic framework | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | cancer therapy | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | micelle | - |
dc.subject.keywordAuthor | nanogel | - |
dc.subject.keywordPlus | MESOPOROUS SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | METAL-ORGANIC FRAMEWORKS | - |
dc.subject.keywordPlus | PACLITAXEL CONJUGATE MICELLES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | POLYMERIC MICELLES | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | INTRACELLULAR DELIVERY | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | PROTEIN DELIVERY | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.