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DC Field | Value | Language |
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dc.citation.endPage | 1620 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1608 | - |
dc.citation.title | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.citation.volume | 33 | - |
dc.contributor.author | Koh, Ara | - |
dc.contributor.author | Lee, Mi Nam | - |
dc.contributor.author | Yang, Yong Ryoul | - |
dc.contributor.author | Jeong, Heeyoon | - |
dc.contributor.author | Ghim, Jaewang | - |
dc.contributor.author | Noh, Jeongeun | - |
dc.contributor.author | Kim, Jaeyoon | - |
dc.contributor.author | Ryu, Dongryeol | - |
dc.contributor.author | Park, Sehoon | - |
dc.contributor.author | Song, Parkyong | - |
dc.contributor.author | Koo, Seung-Hoi | - |
dc.contributor.author | Leslie, Nick R. | - |
dc.contributor.author | Berggren, Per-Olof | - |
dc.contributor.author | Choi, Jang Hyun | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.date.accessioned | 2023-12-22T04:08:37Z | - |
dc.date.available | 2023-12-22T04:08:37Z | - |
dc.date.created | 2013-06-28 | - |
dc.date.issued | 2013-04 | - |
dc.description.abstract | Muscle atrophy occurs under various catabolic conditions, including insulin deficiency, insulin resistance, or increased levels of glucocorticoids. This results from reduced levels of insulin receptor substrate 1 (IRS-1), leading to decreased phosphatidylinositol 3-kinase activity and thereby activation of FoxO transcription factors. However, the precise mechanism of reduced IRS-1 under a catabolic condition is unknown. Here, we report that C1-Ten is a novel protein tyrosine phosphatase (PTPase) of IRS-1 that acts as a mediator to reduce IRS-1 under a catabolic condition, resulting in muscle atrophy. C1-Ten preferentially dephosphorylated Y612 of IRS-1, which accelerated IRS-1 degradation. These findings suggest a novel type of IRS-1 degradation mechanism which is dependent on C1-Ten and extends our understanding of the molecular mechanism of muscle atrophy under catabolic conditions. C1-Ten expression is increased by catabolic glucocorticoid and decreased by anabolic insulin. Reflecting these hormonal regulations, the muscle C1-Ten is upregulated in atrophy but downregulated in hypertrophy. This reveals a previously unidentified role of C1-Ten as a relevant PTPase contributing to skeletal muscle atrophy. | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR BIOLOGY, v.33, no.8, pp.1608 - 1620 | - |
dc.identifier.doi | 10.1128/MCB.01447-12 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.scopusid | 2-s2.0-84876333589 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/2701 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84876333589 | - |
dc.identifier.wosid | 000317272500011 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.title | C1-Ten Is a Protein Tyrosine Phosphatase of Insulin Receptor Substrate 1 (IRS-1), Regulating IRS-1 Stability and Muscle Atrophy | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY | - |
dc.subject.keywordPlus | FOXO TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | HUMAN SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | GROWTH-FACTOR-II | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | UBIQUITIN LIGASES | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CELL-SURVIVAL | - |
dc.subject.keywordPlus | RESISTANCE | - |
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