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Non-Invasive Brain-to-Brain Interface (BBI): Establishing Functional Links between Two Brains

Cited 12 times inthomson ciCited 8 times inthomson ci
Title
Non-Invasive Brain-to-Brain Interface (BBI): Establishing Functional Links between Two Brains
Author
Yoo, Seung-SchikKim, HyungminFilandrianos, EmmanuelTaghados, Seyed JavidPark, Shinsuk
Keywords
FOCUSED ULTRASOUND; COMPUTER-INTERFACE; MACHINE INTERFACE; REAL-TIME; RAT; COMMUNICATION; STIMULATION; SIGNALS; NAVIGATION; INTENSITY
Issue Date
201304
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v.8, no.4, pp.e60410 -
Abstract
Transcranial focused ultrasound (FUS) is capable of modulating the neural activity of specific brain regions, with a potential role as a non-invasive computer-to-brain interface (CBI). In conjunction with the use of brain-to-computer interface (BCI) techniques that translate brain function to generate computer commands, we investigated the feasibility of using the FUS-based CBI to non-invasively establish a functional link between the brains of different species (i.e. human and Sprague-Dawley rat), thus creating a brain-to-brain interface (BBI). The implementation was aimed to non-invasively translate the human volunteer's intention to stimulate a rat's brain motor area that is responsible for the tail movement. The volunteer initiated the intention by looking at a strobe light flicker on a computer display, and the degree of synchronization in the electroencephalographic steady-state-visual-evoked-potentials (SSVEP) with respect to the strobe frequency was analyzed using a computer. Increased signal amplitude in the SSVEP, indicating the volunteer's intention, triggered the delivery of a burst-mode FUS (350 kHz ultrasound frequency, tone burst duration of 0.5 ms, pulse repetition frequency of 1 kHz, given for 300 msec duration) to excite the motor area of an anesthetized rat transcranially. The successful excitation subsequently elicited the tail movement, which was detected by a motion sensor. The interface was achieved at 94.0 +/- 3.0% accuracy, with a time delay of 1.59 +/- 1.07 sec from the thought-initiation to the creation of the tail movement. Our results demonstrate the feasibility of a computer-mediated BBI that links central neural functions between two biological entities, which may confer unexplored opportunities in the study of neuroscience with potential implications for therapeutic applications.
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DOI
http://dx.doi.org/10.1371/journal.pone.0060410
ISSN
1932-6203
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SLS_Journal Papers
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