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Madou, Mark
BIO-MEMS Lab
Research Interests
  • Medical Diagnostics

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The Effect of Contact Angles and Capillary Dimensions on the Burst Frequency of Super Hydrophilic and Hydrophilic Centrifugal Microfluidic Platforms, a CFD Study

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Title
The Effect of Contact Angles and Capillary Dimensions on the Burst Frequency of Super Hydrophilic and Hydrophilic Centrifugal Microfluidic Platforms, a CFD Study
Author
Kazemzadeh, AminGanesan, PooIbrahim, FatimahHe, ShuishengMadou, Mark
Keywords
TOTAL ANALYSIS SYSTEMS; MICRO CHECK VALVES; SURFACE-TENSION; PASSIVE VALVES; ROTATING-DISK; STOP VALVES; FABRICATION; FLOW; MICROVALVES; BARRIER
Issue Date
201309
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v.8, no.9, pp.e73002 -
Abstract
This paper employs the volume of fluid (VOF) method to numerically investigate the effect of the width, height, and contact angles on burst frequencies of super hydrophilic and hydrophilic capillary valves in centrifugal microfluidic systems. Existing experimental results in the literature have been used to validate the implementation of the numerical method. The performance of capillary valves in the rectangular and the circular microfluidic structures on super hydrophilic centrifugal microfluidic platforms is studied. The numerical results are also compared with the existing theoretical models and the differences are discussed. Our experimental and computed results show a minimum burst frequency occurring at square capillaries and this result is useful for designing and developing more sophisticated networks of capillary valves. It also predicts that in super hydrophilic microfluidics, the fluid leaks consistently from the capillary valve at low pressures which can disrupt the biomedical procedures in centrifugal microfluidic platforms.
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DOI
http://dx.doi.org/10.1371/journal.pone.0073002
ISSN
1932-6203
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SLS_Journal Papers
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