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DC Field | Value | Language |
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dc.citation.endPage | 2426 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 2420 | - |
dc.citation.title | ACS NANO | - |
dc.citation.volume | 13 | - |
dc.contributor.author | Yang, Shenyu | - |
dc.contributor.author | Li, Bo | - |
dc.contributor.author | Wu, Chunxian | - |
dc.contributor.author | Xu, Weiwei | - |
dc.contributor.author | Tu, Mei | - |
dc.contributor.author | Yan, Yun | - |
dc.contributor.author | Huang, Jianbin | - |
dc.contributor.author | Drechsler, Markus | - |
dc.contributor.author | Granick, Steve | - |
dc.contributor.author | Jiang, Lingxiang | - |
dc.date.accessioned | 2023-12-21T19:37:19Z | - |
dc.date.available | 2023-12-21T19:37:19Z | - |
dc.date.created | 2019-03-22 | - |
dc.date.issued | 2019-02 | - |
dc.description.abstract | Coacervation is liquid-liquid phase separation ubiquitous in industrial applications and cellular biology. Inspired by cellular manipulation of coacervate droplets such as P granules, we report here a regulatory strategy to manipulate synthetic coacervation in a spatiotemporally controllable manner. Two oppositely charged small molecules are shown to phase separate into coacervate droplets in water as a result of electrostatic attraction, hydrophobic effect, and entropy. We identify a down regulator, beta-cyclodextrin, to disrupt the hydrophobic effect, thus dissolving the droplets, and an up regulator, amylase, to decompose beta-cyclodextrin, thus restoring the droplets. The regulation kinetics is followed in real time on a single-droplet level, revealing diffusion-limited dissolution and reaction-limited condensation, respectively, taking similar to 4 s and 2-3 min. Versatility of this strategy to manipulate the coacervation is demonstrated in two aspects: spatially distributed coacervation in virtue of amylase-grafted hydrogel frameworks and coacervate transportation across membranes and hydrogel networks via a disassemble-to-pass strategy. The current regulatory pairs and strategies are anticipated to be general for a wide variety of synthetic self-assembly systems. | - |
dc.identifier.bibliographicCitation | ACS NANO, v.13, no.2, pp.2420 - 2426 | - |
dc.identifier.doi | 10.1021/acsnano.8b09332 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.scopusid | 2-s2.0-85061284808 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/26407 | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsnano.8b09332 | - |
dc.identifier.wosid | 000460199400141 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Steering Coacervation by a Pair of Broad-Spectrum Regulators | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry; Science & Technology - Other Topics; Materials Science | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | coacervation | - |
dc.subject.keywordAuthor | regulators | - |
dc.subject.keywordAuthor | cyclodextrin | - |
dc.subject.keywordAuthor | transportation | - |
dc.subject.keywordAuthor | patterning | - |
dc.subject.keywordAuthor | enzymes | - |
dc.subject.keywordAuthor | biomimicry | - |
dc.subject.keywordPlus | PHASE-SEPARATION | - |
dc.subject.keywordPlus | CYCLODEXTRIN | - |
dc.subject.keywordPlus | DROPLETS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | POLYELECTROLYTES | - |
dc.subject.keywordPlus | AGGREGATION | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | SYSTEMS | - |
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