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DC Field | Value | Language |
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dc.citation.endPage | 816 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 805 | - |
dc.citation.title | NEOPLASIA | - |
dc.citation.volume | 19 | - |
dc.contributor.author | Kim, Jaeil | - |
dc.contributor.author | Do, Eun-ju | - |
dc.contributor.author | Moinova, Helen | - |
dc.contributor.author | Bae, Sang Mun | - |
dc.contributor.author | Kang, Ja Young | - |
dc.contributor.author | Hong, Seung-Mo | - |
dc.contributor.author | Fink, Stephen P. | - |
dc.contributor.author | Joo, Jinmyoung | - |
dc.contributor.author | Suh, Young-Ah | - |
dc.contributor.author | Jang, Se Jin | - |
dc.contributor.author | Hwang, Sung Wook | - |
dc.contributor.author | Park, Sang Hyoung | - |
dc.contributor.author | Yang, Dong-Hoon | - |
dc.contributor.author | Ye, Byong Duk | - |
dc.contributor.author | Byeon, Jeong-Sik | - |
dc.contributor.author | Choe, Jaewon | - |
dc.contributor.author | Yang, Suk-Kyun | - |
dc.contributor.author | Markowitz, Sanford D. | - |
dc.contributor.author | Kim, Sang-Yeob | - |
dc.contributor.author | Myung, Seung-Jae | - |
dc.date.accessioned | 2023-12-21T21:40:15Z | - |
dc.date.available | 2023-12-21T21:40:15Z | - |
dc.date.created | 2019-01-08 | - |
dc.date.issued | 2017-10 | - |
dc.description.abstract | A versatile biomarker for detecting colonic adenoma and colon cancer has yet to be developed. Colon cancer secreted protein-2 (CCSP-2) is a protein specifically expressed and secreted in colon adenomas and cancers. We developed a fluorescent imaging method based on CCSP-2 targeting for a more sensitive and specific detection of colorectal tumors. CCSP-2 expression was evaluated in human colon adenoma and colorectal specimens. Anti CCSP-2 antibody was labeled with a near-infrared fluorescent dye, FPR-675, and molecular imaging of surgical human colorectal tumors was performed. Immunohistochemistry identified CCSP-2 expression in 87.0% of colorectal cancer specimens and 89.5% of colon adenoma specimens. Fluorescence imaging of surgical human colon specimens after spraying treatment with the probe permitted a clear distinction of cancer from paired normal colon tissue (target-to-background ratio, 4.09 +/- 0.42; P < .001). CCSP-2 targeting imaging was also evaluated in patient-derived colon cancer xenograft mouse and liver metastasis murine models. CCSP-2-positive colon cancer xenografts and liver metastases were visualized by near-infrared fluorescence imaging after intravenous injection of the probe, which showed significantly higher fluorescence. Our results show that CCSP-2 is a promising marker for colorectal tumor detection in clinical settings and that a CCSP-2-targeting molecular imaging strategy might improve the diagnosis of colorectal tumors in metastatic or recurrent cancers and aid in early colonoscopic detection of premalignant lesions. | - |
dc.identifier.bibliographicCitation | NEOPLASIA, v.19, no.10, pp.805 - 816 | - |
dc.identifier.doi | 10.1016/j.neo.2017.07.003 | - |
dc.identifier.issn | 1476-5586 | - |
dc.identifier.scopusid | 2-s2.0-85032968254 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/25684 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S147655861730177X?via%3Dihub | - |
dc.identifier.wosid | 000411874100007 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Molecular Imaging of Colorectal Tumors by Targeting Colon Cancer Secreted Protein-2 (CCSP-2) | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | COLONOSCOPIC POLYPECTOMY | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | DYSPLASIA | - |
dc.subject.keywordPlus | ENDOSCOPY | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | COLITIS | - |
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