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Bielawski, Christopher W.
Synthetic Materials & Macromolecules
Research Interests
  • Synthetic chemistry, materials science, polymer chemistry, catalysis, carbon-based materials

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Ru(II)-based antineoplastic: A "wingtip" N-heterocyclic carbene facilitates access to a new class of organometallics that are cytotoxic to common cancer cell lines

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Title
Ru(II)-based antineoplastic: A "wingtip" N-heterocyclic carbene facilitates access to a new class of organometallics that are cytotoxic to common cancer cell lines
Author
Mondal, AmbarishTripathy, Rajat K.Dutta, ParulSantra, Manas KumarIsab, Anvarhusein A.Bielawski, Christopher W.Kisan, Hemanta K.Chandra, Swapan K.Dinda, Joydev
Keywords
cytotoxicity;  Gold(I)-NHC;  N-heterocyclic carbene;  silver(I)-NHC
Issue Date
201901
Publisher
WILEY-BLACKWELL
Citation
APPLIED ORGANOMETALLIC CHEMISTRY, v.33, no.1, pp.e4692 -
Abstract
The syntheses, structures, and chemotherapeutic activities of Ag(I)-, Au(I)-, and Ru(II)-complexes ligated to a novel N-heterocyclic carbene ligand, 2-(4-nitrophenyl)imidazo[1,5-a]pyridin-2-ylidene (1), are described. The corresponding complexes, [Ag(1)(2)][PF6], [Au(1)(2)][PF6] (3), and [Ru(1)(p-cymene)Cl][PF6] (4), were prepared using convenient transmetallation chemistry and characterized using a range of spectroscopic and analytical techniques. X-ray crystallography revealed that complexes 2 and 3 adopted linear structures whereas 4 exhibited a prototypical "piano-stool"-like geometry; the structural assignments were further supported by DFT calculations. A series of in vitro studies revealed that while the aforementioned Ag(I), Au(I) and Ru(II) complexes exhibited significant cytotoxicities against the human colon adenocarcinoma (HCT 116), lung cancer (A549), and breast cancer (MCF7) cell lines, the Ru derivative was most prominent.
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DOI
http://dx.doi.org/10.1002/aoc.4692
ISSN
0268-2605
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