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Min, Kyung-Tai
Molecular & Cellular Neurobiology Lab(Min Lab)
Research Interests
  • Local protein synthesis, learning & memory, behavior, mitochondrial dynamics

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Miro, MCU, and calcium: Bridging our understanding of mitochondrial movement in axons

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Title
Miro, MCU, and calcium: Bridging our understanding of mitochondrial movement in axons
Author
Niescier, Robert F.Chang, Karen T.Min, Kyung-Tai
Keywords
Axonal transport; MCU; MICU1; Miro; Mitochondria
Issue Date
201309
Publisher
FRONTIERS RES FOUND
Citation
FRONTIERS IN CELLULAR NEUROSCIENCE, v.7, no., pp.1 - 5
Abstract
Neurons are extremely polarized structures with long axons and dendrites, which require proper distribution of mitochondria and maintenance of mitochondrial dynamics for neuronal functions and survival. Indeed, recent studies show that various neurological disorders are linked to mitochondrial transport in neurons. Mitochondrial anterograde transport is believed to deliver metabolic energy to synaptic terminals where energy demands are high, while mitochondrial retrograde transport is required to repair or remove damaged mitochondria in axons. It has been suggested that Ca2+ plays a key role in regulating mitochondrial transport by altering the configuration of mitochondrial protein, miro. However, molecular mechanisms that regulate mitochondrial transport in neurons still are not well characterized. In this review, we will discuss the roles of miro in mitochondrial transport and how the recently identified components of the mitochondrial calcium uniporter add to our current model of mitochondrial mobility regulation.
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DOI
http://dx.doi.org/10.3389/fncel.2013.00148
ISSN
1662-5102
Appears in Collections:
SLS_Journal Papers
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