There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.number | 462 | - |
dc.citation.startPage | eaam7486 | - |
dc.citation.title | SCIENCE TRANSLATIONAL MEDICINE | - |
dc.citation.volume | 10 | - |
dc.contributor.author | Song, Eun Kyung | - |
dc.contributor.author | Jeon, Jimin | - |
dc.contributor.author | Jang, Dong Gil | - |
dc.contributor.author | Kim, Ha Eun | - |
dc.contributor.author | Sim, Hyo Jung | - |
dc.contributor.author | Kwon, Keun Yeong | - |
dc.contributor.author | Medina-Ruiz, Sofia | - |
dc.contributor.author | Jang, Hyun-Jun | - |
dc.contributor.author | Lee, Ah Reum | - |
dc.contributor.author | Rho, Jun Gi | - |
dc.contributor.author | Lee, Hyun-Shik | - |
dc.contributor.author | Kim, Seok Jung | - |
dc.contributor.author | Park, Chan Young | - |
dc.contributor.author | Myung, Kyungjae | - |
dc.contributor.author | Kim, Wook | - |
dc.contributor.author | Kwon, Taejoon | - |
dc.contributor.author | Yang, Siyoung | - |
dc.contributor.author | Park, Tae Joo | - |
dc.date.accessioned | 2023-12-21T20:10:06Z | - |
dc.date.available | 2023-12-21T20:10:06Z | - |
dc.date.created | 2018-10-08 | - |
dc.date.issued | 2018-10 | - |
dc.description.abstract | Developing and mature chondrocytes constantly interact with and remodel the surrounding extracellular matrix (ECM). Recent research indicates that integrin-ECM interaction is differentially regulated during cartilage formation (chondrogenesis). Integrin signaling is also a key source of the catabolic reactions responsible for joint destruction in both rheumatoid arthritis and osteoarthritis. However, we do not understand how chondrocytes dynamically regulate integrin signaling in such an ECM-rich environment. Here, we found that developing chondrocytes express integrin-β-like 1 (Itgbl1) at specific stages, inhibiting integrin signaling and promoting chondrogenesis. Unlike cytosolic integrin inhibitors, ITGBL1 is secreted and physically interacts with integrins to down-regulate activity. We observed that Itgbl1 expression was strongly reduced in the damaged articular cartilage of patients with osteoarthritis (OA). Ectopic expression of Itgbl1 protected joint cartilage against OA development in the destabilization of the medial meniscus-induced OA mouse model. Our results reveal ITGBL1 signaling as an underlying mechanism of protection against destructive cartilage disorders and suggest the potential therapeutic utility of targeting ITGBL1 to modulate integrin signaling in human disease. | - |
dc.identifier.bibliographicCitation | SCIENCE TRANSLATIONAL MEDICINE, v.10, no.462, pp.eaam7486 | - |
dc.identifier.doi | 10.1126/scitranslmed.aam7486 | - |
dc.identifier.issn | 1946-6234 | - |
dc.identifier.scopusid | 2-s2.0-85054776465 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24963 | - |
dc.identifier.url | http://stm.sciencemag.org/content/10/462/eaam7486 | - |
dc.identifier.wosid | 000448831900001 | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis. | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Cell Biology; Medicine, Research & Experimental | - |
dc.relation.journalResearchArea | Cell Biology; Research & Experimental Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | CRANIOFACIAL DEVELOPMENT | - |
dc.subject.keywordPlus | MATRIX INTERACTIONS | - |
dc.subject.keywordPlus | FOCAL ADHESION KINASE | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | CALCIUM-BINDING SITE | - |
dc.subject.keywordPlus | EGF-LIKE DOMAIN | - |
dc.subject.keywordPlus | ARTICULAR CHONDROCYTES | - |
dc.subject.keywordPlus | FIBRONECTIN FRAGMENTS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | OSTEOARTHRITIC CARTILAGE | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.