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DC Field | Value | Language |
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dc.citation.endPage | 245 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 238 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 302 | - |
dc.contributor.author | Lim, Jung Yeon | - |
dc.contributor.author | Kim, Hongtae | - |
dc.contributor.author | Kim, Young Hoon | - |
dc.contributor.author | Kim, Sae Woong | - |
dc.contributor.author | Huh, Pil-Woo | - |
dc.contributor.author | Lee, Kweon-Haeng | - |
dc.contributor.author | Jeun, Sin-Soo | - |
dc.contributor.author | Rha, Hyoung-Kyun | - |
dc.contributor.author | Kang, Joon-Ki | - |
dc.date.accessioned | 2023-12-22T11:13:18Z | - |
dc.date.available | 2023-12-22T11:13:18Z | - |
dc.date.created | 2018-09-19 | - |
dc.date.issued | 2003-03 | - |
dc.description.abstract | The neurofibromatosis type 2 (NF2) gene encodes an intracellular membrane-associated protein called merlin or schwannomin, which is known to be a tumor suppressor. Numerous studies have suggested that merlin is involved in the regulation of cell growth and proliferation. Previously, merlin/schwannomin was reported to block Ras-induced cell proliferation and anchorage-independent cell growth. Also, the N-terminus of merlin was found to Suppress cell proliferation, although it appears to be less effective than full-length merlin. However, the inhibitory mechanism of merlin is unknown. In this report, merlin is shown to be effective at suppressing serum/Ras-induced and Elk-mediated SRE dependent transactivation, and serum-induced ERK phosphorylation in NIH3T3 cells. In addition, merlin inhibited serum-induced Elk phosphorylation. a downstream effector of ERKs. Also, the N-terminal deficient merlin mutant could not block serum-induced and Elk-mediated SRE dependent transactivation, although the C-terminal deficient merlin mutant could. These results suggest that merlin inhibits SRE dependent transactivation by repressing serum-induced ERK phosphorylation and its downstream effector, Elk phosphorylation. Also, the N-terminus of merlin may be important for its inhibitory effect. Our results show that merlin acts as a negative regulator of the SRE signaling pathway via the Ras-ERKs pathway. | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.302, no.2, pp.238 - 245 | - |
dc.identifier.doi | 10.1016/S0006-291X(03)00124-4 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.scopusid | 2-s2.0-0037428310 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24918 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X03001244?via%3Dihub | - |
dc.identifier.wosid | 000181534500010 | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Merlin suppresses the SRE-dependent transcription by inhibiting the activation of Ras-ERK pathway | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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