There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 693 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 688 | - |
dc.citation.title | MACROMOLECULAR RESEARCH | - |
dc.citation.volume | 19 | - |
dc.contributor.author | Lee, Min Sang | - |
dc.contributor.author | Kim, Myung Goo | - |
dc.contributor.author | Jang, Yeon Lim | - |
dc.contributor.author | Lee, Kyuri | - |
dc.contributor.author | Kim, Taek Gyoung | - |
dc.contributor.author | Kim, Sun Hwa | - |
dc.contributor.author | Park, Tae Gwan | - |
dc.contributor.author | Kim, Hong Tae | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.date.accessioned | 2023-12-22T06:07:38Z | - |
dc.date.available | 2023-12-22T06:07:38Z | - |
dc.date.created | 2018-09-19 | - |
dc.date.issued | 2011-07 | - |
dc.description.abstract | Branched polyethylenimine (bPEI) has long been considered as a gold standard for non-viral gene transfection owing to its excellent gene condensing property and consistent transfection efficiency in various cells. On the other hand, the undesirable cytotoxicity profiles of bPEI limits its use in clinical applications. This study presents a facile way of improving the cytotoxicity of bPEI by grafting a biodegradable polyester chains (PEI-g-poly(lacticco-glycolic acid), PEI-g-PLGA). Remarkable improvement in cell viability and reduction in cell membrane damages could be observed with PEI-g-PLGA. In addition, PEI-g-PLGA did not cause serious erythrocyte aggregation, which is in contrast to bPEI. The copolymer formed spherical cationic micelles that facilitate the formation of polyelectrolyte complexes by interacting with plasmid DNA. The hydrodynamic size of the complexes ranged from 120 to 200 nm. Although PEI-g-PLGA demonstrated slightly lower transfection efficiency than bPEI 10 kDa, the copolymer can be considered as a potential non-toxic candidate gene carrier for clinical gene therapy, where a large dose or repeated administration would be needed for an extended period of time. | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR RESEARCH, v.19, no.7, pp.688 - 693 | - |
dc.identifier.doi | 10.1007/s13233-011-0715-1 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.scopusid | 2-s2.0-79960042053 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24900 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs13233-011-0715-1 | - |
dc.identifier.wosid | 000292274200007 | - |
dc.language | 영어 | - |
dc.publisher | SPRINGER | - |
dc.title | Polyethylenimine-g-poly(lactic-co-glycolic acid) as non-toxic micelle-type carrier for gene delivery | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.