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Author

Takayama, Shuichi
Cell and Microfluidics Lab
Research Interests
  • Bio-MEMS and Microfluidics

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Aqueous biphasic microprinting approach to tissue engineering

Cited 5 times inthomson ciCited 4 times inthomson ci
Title
Aqueous biphasic microprinting approach to tissue engineering
Author
Tavana, HosseinTakayama, Shuichi
Keywords
Aqueous phase; Aqueous phasis; Aqueous solutions; Biological surfaces; Bioreagents; Biphasic; Cell fates; Cell layers; Cell monolayers; Cell-material interaction; Density difference; Embedded cells; Extracellular matrices; Hydrogel surfaces; Interfacial tensions; Microprinting; Microtechnology; Printing process; Scaffolding materials; Second phase; Shaped pattern; Skeletal muscle; Small molecules; Tissue engineering applications
Issue Date
201103
Publisher
AMER INST PHYSICS
Citation
BIOMICROFLUIDICS, v.5, no.1, pp.1 - 8
Abstract
We summarize a recently developed microtechnology for printing biomaterials on biological surfaces. The technique is based on the use of immiscible aqueous solutions of two biopolymers and allows spatially defined placement of cells and biomolecules suspended in the denser aqueous phase on existing cell layers and extracellular matrix hydrogel surfaces maintained in the second phase. Printing takes place due to an extremely small interfacial tension and density difference between the two aqueous phases. The contact-free printing process ensures that both printed cells and the underlying cell monolayer maintain full viability and functionality. The technique accommodates both arbitrarily shaped patterns and microarrays of cells and bioreagents. The capability to print cells and small molecules on existing cell layers enables unique interrogations of the effects of cell-cell and cell-material interaction on cell fate and function. Furthermore, the very gentle conditions and the ability to directly pattern nongel embedded cells over cells make this technology appealing to tissue engineering applications where patterned multicellar organization with minimal scaffolding materials is needed, such as in dense tissues of the skeletal muscle and liver
URI
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DOI
http://dx.doi.org/10.1063/1.3516658
ISSN
1932-1058
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SLS_Journal Papers
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