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Chae, Young Chan
Research Interests
  • Cancer Metabolism, Stress Response of Cancer, Mitochondria of Cancer, Molecular Mechanisms of Cancer Initiation, Progression and Therapy, Autophagy in Cell Survival and Cancer Progression, Mechanism of tumor therapeutic resistance

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Cancer stem cell metabolism: target for cancer therapy

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Title
Cancer stem cell metabolism: target for cancer therapy
Author
Chae, Young ChanKim, Jae Ho
Issue Date
201807
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS, v.51, no.7, pp.319 - 326
Abstract
Increasing evidence suggests that cancer stem cell (CSC) theory represents an important mechanism underlying the observed failure of existing therapeutic modalities to fully eradicate cancers. In addition to their more established role in maintaining minimal residual disease after treatment and forming the new bulk of the tumor, CSCs might also critically contribute to tumor recurrence and metastasis. For this reason, specific elimination of CSCs may thus represent one of the most important treatment strategies. Emerging evidence has shown that CSCs have a different metabolic phenotype to that of differentiated bulk tumor cells, and these specific metabolic activities directly participate in the process of CSC transformation or support the biological processes that enable tumor progression. Exploring the role of CSC metabolism and the mechanism of the metabolic plasticity of CSCs has become a major focus in current cancer research. The targeting of CSC metabolism may provide new effective therapies to reduce the risk of recurrence and metastasis. In this review, we summarize the most significant discoveries regarding the metabolism of CSCs and highlight recent approaches in targeting CSC metabolism.
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DOI
http://dx.doi.org/10.5483/BMBRep.2018.51.7.112
ISSN
1976-6696
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SLS_Journal Papers
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