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DC Field | Value | Language |
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dc.citation.endPage | 10711 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 10704 | - |
dc.citation.title | NEW JOURNAL OF CHEMISTRY | - |
dc.citation.volume | 42 | - |
dc.contributor.author | Rana, Bidyut Kumar | - |
dc.contributor.author | Mishra, Snehasis | - |
dc.contributor.author | Sarkar, Deblina | - |
dc.contributor.author | Mondal, Tapan Kumar | - |
dc.contributor.author | Seth, Saikat K. | - |
dc.contributor.author | Bertolasi, Valerio | - |
dc.contributor.author | Das Saha, Krishna | - |
dc.contributor.author | Bielawski, Christopher W. | - |
dc.contributor.author | Isab, Anvarhusein A. | - |
dc.contributor.author | Dinda, Joydev | - |
dc.date.accessioned | 2023-12-21T20:37:40Z | - |
dc.date.available | 2023-12-21T20:37:40Z | - |
dc.date.created | 2018-07-27 | - |
dc.date.issued | 2018-07 | - |
dc.description.abstract | To elucidate the intrinsic biological activities displayed by platinum versus gold-based organometallic reagents, the isoelectronic and isostructural square planar complexes [Pt(C boolean AND N)(C)Cl][PF6] (2) and [Au(C boolean AND N)(C)Cl][PF6](2) (3), which are supported by a common N-heterocyclic carbene, 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylidene (1), were synthesized. The complexes were characterized using a range of spectroscopic techniques as well as single crystal X-ray diffraction and a series of computational studies were also performed to gain additional insight into their fundamental electronic bonding structures. The cytotoxicities of the complexes were tested in vitro against non-small lung carcinoma (A549), colorectal carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines. The measured IC50 values showed that the Au(III)-NHC complex is more potent than its Pt analogue. | - |
dc.identifier.bibliographicCitation | NEW JOURNAL OF CHEMISTRY, v.42, no.13, pp.10704 - 10711 | - |
dc.identifier.doi | 10.1039/c8nj01562g | - |
dc.identifier.issn | 1144-0546 | - |
dc.identifier.scopusid | 2-s2.0-85049165130 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24436 | - |
dc.identifier.url | http://pubs.rsc.org/en/Content/ArticleLanding/2018/NJ/C8NJ01562G#!divAbstract | - |
dc.identifier.wosid | 000436517300032 | - |
dc.language | 영어 | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Isoelectronic Pt(II)- and Au(III)-N-heterocyclic carbene complexes: a structural and biological comparison | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | N-HETEROCYCLIC CARBENE | - |
dc.subject.keywordPlus | DENSITY-FUNCTIONAL THEORY | - |
dc.subject.keywordPlus | GOLD(III) COMPLEXES | - |
dc.subject.keywordPlus | ANTICANCER AGENTS | - |
dc.subject.keywordPlus | ANTITUMOR AGENTS | - |
dc.subject.keywordPlus | GOLD CATALYSIS | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | SILVER(I) | - |
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