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Amblard, Francois
School of Life Science
Research Interests
  • Biology

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Microtopographies control the development of basal protrusions in epithelial sheets

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Title
Microtopographies control the development of basal protrusions in epithelial sheets
Author
Coscoy, SylvieBaiz, SarahOcton, JeanRhone, BenoitPerquis, LucieTseng, QingzongAmblard, FrancoisSemetey, Vincent
Issue Date
201807
Publisher
AMER INST PHYSICS
Citation
BIOINTERPHASES, v.13, no.4, pp.041003 -
Abstract
Cells are able to develop various types of membrane protrusions that modulate their adhesive, migratory, or functional properties. However, their ability to form basal protrusions, particularly in the context of epithelial sheets, is not widely characterized. The authors built hexagonal lattices to probe systematically the microtopography-induced formation of epithelial cell protrusions. Lattices of hexagons of various sizes (from 1.5 to 19 mu m) and 5-10 mu m height were generated by two-photon photopolymerization in NOA61 or poly(ethylene glycol) diacrylate derivatives. The authors found that cells generated numerous, extensive, and deep basal protrusions for hexagons inferior to cell size (3-10 mu m) while maintaining a continuous epithelial layer above structures. They characterized the kinetics of protrusion formation depending on scaffold geometry and size. The reported formation of extensive protrusions in 3D microtopography could be beneficial to develop new bio-materials with increased adhesive properties or to improve tissue engineering.
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DOI
http://dx.doi.org/10.1116/1.5024601
ISSN
1934-8630
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