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DC Field | Value | Language |
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dc.citation.endPage | 8438 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 8430 | - |
dc.citation.title | INORGANIC CHEMISTRY | - |
dc.citation.volume | 56 | - |
dc.contributor.author | Jo, Jae-Ho | - |
dc.contributor.author | Singh, Nem | - |
dc.contributor.author | Kim, Donghyuk | - |
dc.contributor.author | Cho, Se Min | - |
dc.contributor.author | Mishra, Anurag | - |
dc.contributor.author | Kim, Hyunuk | - |
dc.contributor.author | Kang, Se Chan | - |
dc.contributor.author | Chi, Ki-Whan | - |
dc.date.accessioned | 2023-12-21T22:07:20Z | - |
dc.date.available | 2023-12-21T22:07:20Z | - |
dc.date.created | 2018-07-04 | - |
dc.date.issued | 2017-07 | - |
dc.description.abstract | Coordination-driven self-assembly of m-bis[3-(4-pyridyl)pyrazolyl]xylene (L) and [(p-cymene)(2)Ru-2-(OO boolean AND OO)(2)(OTf)(2)] (A(1)) (OO boolean AND OO = 6,11-dioxido-5,12-naphthacenedione) in methanol resulted in a mixture of [2]catenane 1 and macrocyde 2, and self-assembly in nitromethane resulted in pure macrocycle 2, whereas the coordination-driven self-assembly of L and similar acceptors [(p-cymene)(2)Ru-2(OO boolean AND OO)(2)(OTf)(2)] [OO boolean AND OO = 5,8-dioxido-1,4-naphthoquinonnato (A(2)); 2,5-dioxido-1,4-benzoquinonato (A(3)); oxalato (A(4))] resulted in the formations of monomeric macrocydes 3-5, respectively. All self-assembled macrocydes were obtained in excellent yields (>90%) as triflate salts and were fully characterized by multinuclear NMR, elemental analysis, and electrospray ionization mass spectrometry (ESI-MS). The structures of [2]catenane 1 and macrocydes 5 were confirmed by single-crystal X-ray diffraction analysis. The X-ray structure of 1 confirmed an edge-to-face interaction between the tetracene moiety in parallel-displaced pi-pi stacks (3.5 angstrom), and CH center dot center dot center dot pi (2.5 angstrom) stabilizes the [2]catenane topology. Macrocydes 2-5 were assessed for anticancer activities using human cancer cell lines of different origins, and the macrocyde 3 was found to exhibit the best inhibitory effect and to do so in a dose-dependent manner. Further examination with the Tali apoptosis assay suggested the growth inhibitory effect of 3 involved the induction of the programmed cell death, and this suggestion was supported by observations of PARP and caspase 3 cleavage after treating cells with 3. In addition, exposure to 3 increased the expression of Bax and repressed the expression of Bcl-2, thus indicating the involvement of macrocyde 3 upstream of Bax and Bcl-2 in the apoptotic signaling pathway. Macrocycle 3 also tended to repress metastasis as evidenced by changes in the transcriptional expressions E- and N-cadherin (markers of metastasis). Furthermore, a stability assay demonstrated macrocyde 3 remained stable at high concentration. | - |
dc.identifier.bibliographicCitation | INORGANIC CHEMISTRY, v.56, no.14, pp.8430 - 8438 | - |
dc.identifier.doi | 10.1021/acs.inorgchem.7b01101 | - |
dc.identifier.issn | 0020-1669 | - |
dc.identifier.scopusid | 2-s2.0-85024364228 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24276 | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acs.inorgchem.7b01101 | - |
dc.identifier.wosid | 000405972200091 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Coordination-Driven Self-Assembly Using Ditopic Pyridyl-Pyrazolyl Donor and p-Cymene Ru(II) Acceptors: [2]Catenane Synthesis and Anticancer Activities | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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