Coordination-driven self-assembly and anticancer studies of thiophene-derived donor and arene ruthenium acceptors
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- Coordination-driven self-assembly and anticancer studies of thiophene-derived donor and arene ruthenium acceptors
- Kim, Taegeun; Song, Hae Seong; Singh, Jatinder; Kim, Donghyuk; Kim, Hyunuk; Kang, Se Chan; Chi, Ki-Whan
- Coordination-driven self-assembly; Thiophene; Anticancer; Metallomacrocycles
- Issue Date
- ELSEVIER SCIENCE SA
- INORGANICA CHIMICA ACTA, v.482, no., pp.179 - 186
- New metallomacrocycles, 5–8, were synthesized by the coordination-driven self-assembly of thiophene-derived donor and arene ruthenium acceptors. Metallomacrocycles, 5–8, were fully characterized by 1H, 13C NMR spectroscopy, ESI-MS and elemental analysis. The molecular structure of macrocycle 8 was determined by single-crystal X-ray diffraction analysis. In addition, the anticancer activities of metallomacrocycles 5–8 were evaluated. The cytotoxic potential of macrocycle 7 was assessed using several cancer cells with different origins using the Tali assay and by quantitative western blotting. The results obtained support the notion that macrocycle 7 induces apoptotic cell death by activating intrinsic and extrinsic apoptosis pathways.
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