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Kim, Donghyuk
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Coordination-driven self-assembly and anticancer studies of thiophene-derived donor and arene ruthenium acceptors

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Title
Coordination-driven self-assembly and anticancer studies of thiophene-derived donor and arene ruthenium acceptors
Author
Kim, TaegeunSong, Hae SeongSingh, JatinderKim, DonghyukKim, HyunukKang, Se ChanChi, Ki-Whan
Keywords
Coordination-driven self-assembly;  Thiophene;  Anticancer;  Metallomacrocycles
Issue Date
201810
Publisher
ELSEVIER SCIENCE SA
Citation
INORGANICA CHIMICA ACTA, v.482, no., pp.179 - 186
Abstract
New metallomacrocycles, 5–8, were synthesized by the coordination-driven self-assembly of thiophene-derived donor and arene ruthenium acceptors. Metallomacrocycles, 5–8, were fully characterized by 1H, 13C NMR spectroscopy, ESI-MS and elemental analysis. The molecular structure of macrocycle 8 was determined by single-crystal X-ray diffraction analysis. In addition, the anticancer activities of metallomacrocycles 5–8 were evaluated. The cytotoxic potential of macrocycle 7 was assessed using several cancer cells with different origins using the Tali assay and by quantitative western blotting. The results obtained support the notion that macrocycle 7 induces apoptotic cell death by activating intrinsic and extrinsic apoptosis pathways.
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DOI
http://dx.doi.org/10.1016/j.ica.2018.05.035
ISSN
0020-1693
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