File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

김동혁

Kim, Donghyuk
Systems Biology and Machine Learning Lab.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Coordination-driven self-assembly and anticancer studies of thiophene-derived donor and arene ruthenium acceptors

Author(s)
Kim, TaegeunSong, Hae SeongSingh, JatinderKim, DonghyukKim, HyunukKang, Se ChanChi, Ki-Whan
Issued Date
2018-10
DOI
10.1016/j.ica.2018.05.035
URI
https://scholarworks.unist.ac.kr/handle/201301/24259
Fulltext
https://www.sciencedirect.com/science/article/pii/S0020169318304225
Citation
INORGANICA CHIMICA ACTA, v.482, pp.179 - 186
Abstract
New metallomacrocycles, 5-8, were synthesized by the coordination-driven self-assembly of thiophene-derived donor and arene ruthenium acceptors. Metallomacrocycles, 5-8, were fully characterized by 1H, 13C NMR spectroscopy, ESI-MS and elemental analysis. The molecular structure of macrocycle 8 was determined by single-crystal X-ray diffraction analysis. In addition, the anticancer activities of metallomacrocycles 5-8 were evaluated. The cytotoxic potential of macrocycle 7 was assessed using several cancer cells with different origins using the Tali assay and by quantitative western blotting. The results obtained support the notion that macrocycle 7 induces apoptotic cell death by activating intrinsic and extrinsic apoptosis pathways.
Publisher
ELSEVIER SCIENCE SA
ISSN
0020-1693

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.