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Lee, Dong Woog
Interfacial Physics and Chemistry Laboratory
Research Interests
  • Bio/Bio-inspired adhesion and lubrication, friction of skin and sensory perception, wetting behavior of various surfaces, surface physics and chemistry of low-dimensional materials

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Probing Nanomechanical Interaction at the Interface between Biological Membrane and Potentially Toxic Chemical

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Title
Probing Nanomechanical Interaction at the Interface between Biological Membrane and Potentially Toxic Chemical
Author
Lim, ChanoongPark, SoheePark, JinwooKo, JinaLee, Dong WoogHwang, Dong Soo
Keywords
Toxicological evaluation; Polyhexamethylene guanidine; Cell membrane; Surface forces apparatus; Langmuir trough
Issue Date
201807
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF HAZARDOUS MATERIALS, v.353, no., pp.271 - 279
Abstract
Various xenobiotics interact with biological membranes, and precise evaluations of the molecular interactions between them are essential to foresee the toxicity and bioavailability of existing or newly synthesized molecules. In this study, surface forces apparatus (SFA) measurement and Langmuir trough based tensiometry are performed to reveal nanomechanical interaction mechanisms between potential toxicants and biological membranes for ex vivo toxicity evaluation. As a toxicant, polyhexamethylene guanidine (PHMG) was selected because PHMG containing humidifier disinfectant and Vodka caused lots of victims in both S. Korea and Russia, respectively, due to the lack of holistic toxicity evaluation of PHMG. Here, we measured strong attraction (Wad ∼4.2 mJ/m2) between PHMG and head group of biological membranes while no detectable adhesion force between the head group and control molecules was measured. Moreover, significant changes in π-A isotherm of 1,2-Dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) monolayers were measured upon PHMG adsorption. These results indicate PHMG strongly binds to hydrophilic group of lipid membranes and alters the structural and phase behavior of them. More importantly, complementary utilization of SFA and Langmuir trough techniques are found to be useful to predict the potential toxicity of a chemical by evaluating the molecular interaction with biological membranes, the primary protective barrier for living organisms.
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DOI
http://dx.doi.org/10.1016/j.jhazmat.2018.04.017
ISSN
0304-3894
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ECHE_Journal Papers

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