Femtosecond laser-induced dissociation (fs-LID) as an activation method in mass spectrometry
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- Femtosecond laser-induced dissociation (fs-LID) as an activation method in mass spectrometry
- Neidel, Christian; Kuehn, Andreas; Schulz, Claus Peter; Hertel, Ingolf V.; Linscheid, Michael W.; Schultz, Thomas
- Fs-LID; Peptides; Proteins; Sequencing; Mass spectrometry; FT-MS; Femtosecond laser
- Issue Date
- ELSEVIER SCIENCE BV
- CHEMICAL PHYSICS, v.514, no., pp.106 - 112
- We report the photolysis of biomolecules in a Fourier-transform ion cyclotron resonance mass spectrometer by intense near-infrared femtosecond laser pulses. Photo-fragmentation was accompanied by photo-ionization and created a large number and variety of charged fragments, which could be identified with high confidence due to the outstanding resolving power and mass accuracy of the mass spectrometer. Fragmentation patterns were sufficient for peptide sequence analysis. Fragments formed by non-ergodic cleavage retained labile post-translational modifications.
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