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Tlusty, Tsvi
Living and Soft Matter Theory Group
Research Interests
  • Systems biology, non-equilibrium physics, physical biology, molecular information, proteins

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Green function of correlated genes in a minimal mechanical model of protein evolution

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dc.contributor.authorDutta, Sandipanko
dc.contributor.authorEckmann, Jean-Pierreko
dc.contributor.authorLibchaber, Albertko
dc.contributor.authorTlusty, Tsviko
dc.date.available2018-05-31T10:18:05Z-
dc.date.created2018-05-30ko
dc.date.issued201805ko
dc.identifier.citationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.115, no.20, pp.E4559 - E4568ko
dc.identifier.issn0027-8424ko
dc.identifier.urihttp://scholarworks.unist.ac.kr/handle/201301/24167-
dc.identifier.urihttp://www.pnas.org/content/115/20/E4559ko
dc.description.abstractThe function of proteins arises from cooperative interactions and rearrangements of their amino acids, which exhibit large-scale dynamical modes. Long-range correlations have also been revealed in protein sequences, and this has motivated the search for physical links between the observed genetic and dynamic cooperativity. We outline here a simplified theory of protein, which relates sequence correlations to physical interactions and to the emergence of mechanical function. Our protein is modeled as a strongly coupled amino acid network with interactions and motions that are captured by the mechanical propagator, the Green function. The propagator describes how the gene determines the connectivity of the amino acids and thereby, the transmission of forces. Mutations introduce localized perturbations to the propagator that scatter the force field. The emergence of function is manifested by a topological transition when a band of such perturbations divides the protein into subdomains. We find that epistasis—the interaction among mutations in the gene—is related to the nonlinearity of the Green function, which can be interpreted as a sum over multiple scattering paths. We apply this mechanical framework to simulations of protein evolution and observe long-range epistasis, which facilitates collective functional modes.ko
dc.languageENGko
dc.publisherNATL ACAD SCIENCESko
dc.subjectprotein evolutionko
dc.subjectepistasisko
dc.subjectgenotype-to-phenotype mapko
dc.subjectGreen functionko
dc.subjectdimensional reductionko
dc.titleGreen function of correlated genes in a minimal mechanical model of protein evolutionko
dc.typeARTICLEko
dc.identifier.pid2941null
dc.identifier.rimsid30342ko
dc.identifier.wosid000432120400006ko
dc.type.rimsAko
dc.identifier.doihttp://dx.doi.org/10.1073/pnas.1716215115ko
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