BROWSE

Related Researcher

Author

Tlusty, Tsvi
Living and Soft Matter Theory Group
Research Interests
  • Systems biology, non-equilibrium physics, physical biology, molecular information, proteins

ITEM VIEW & DOWNLOAD

Green function of correlated genes in a minimal mechanical model of protein evolution

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
Green function of correlated genes in a minimal mechanical model of protein evolution
Author
Dutta, SandipanEckmann, Jean-PierreLibchaber, AlbertTlusty, Tsvi
Keywords
protein evolution; epistasis; genotype-to-phenotype map; Green function; dimensional reduction
Issue Date
201805
Publisher
NATL ACAD SCIENCES
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.115, no.20, pp.E4559 - E4568
Abstract
The function of proteins arises from cooperative interactions and rearrangements of their amino acids, which exhibit large-scale dynamical modes. Long-range correlations have also been revealed in protein sequences, and this has motivated the search for physical links between the observed genetic and dynamic cooperativity. We outline here a simplified theory of protein, which relates sequence correlations to physical interactions and to the emergence of mechanical function. Our protein is modeled as a strongly coupled amino acid network with interactions and motions that are captured by the mechanical propagator, the Green function. The propagator describes how the gene determines the connectivity of the amino acids and thereby, the transmission of forces. Mutations introduce localized perturbations to the propagator that scatter the force field. The emergence of function is manifested by a topological transition when a band of such perturbations divides the protein into subdomains. We find that epistasis—the interaction among mutations in the gene—is related to the nonlinearity of the Green function, which can be interpreted as a sum over multiple scattering paths. We apply this mechanical framework to simulations of protein evolution and observe long-range epistasis, which facilitates collective functional modes.
URI
Go to Link
DOI
http://dx.doi.org/10.1073/pnas.1716215115
ISSN
0027-8424
Appears in Collections:
SNS_Journal Papers
Files in This Item:
000432120400006.pdfDownload

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU