Analysis of triangular motifs in protein interaction networks and their implications to protein ages and cancer genes
Cited 0 times inCited 0 times in
- Analysis of triangular motifs in protein interaction networks and their implications to protein ages and cancer genes
- Jeon, Hyeonseong; Kim, Suh-Ryung; Nam, Dougu; Yoo, Yun Joo
- protein interaction network; phylogenetic age; sub-functionalisation; cancer-related genes
- Issue Date
- INDERSCIENCE ENTERPRISES LTD
- INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS, v.19, no.4, pp.340 - 365
- Proteins interact with each other to regulate their functionality and localisation. The accumulated protein interaction evidences are represented by protein interaction network through a graph abstraction. Topological properties of protein interaction networks have been explored to characterise proteins and predict undiscovered interactions. Meanwhile, many researchers have tried to explain how protein interaction network is formed through evolutionary process. Moreover, the topological properties of protein interaction network are reported to have relationship with cancer-related genes. In this paper, we construct a weighted human protein interaction network based on triangles in protein interaction network and show that there is relationship between triangles in protein interaction network and phylogenetic age of proteins. We also show that triangles in protein interaction network are related to cancer-related genes.
- ; Go to Link
Appears in Collections:
- SLS_Journal Papers
- Files in This Item:
- There are no files associated with this item.
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.