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Lee, Changha
Advanced Redox Technology (ART) Lab
Research Interests
  • Water Treatment, Advanced Oxidation/Reduction, Water Chemistry, Environmental Catalyst

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Nitrite ion mitigates the formation of N-nitrosodimethylamine (NDMA) during chloramination of ranitidine

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dc.contributor.authorSeid, Mingizem Gashawko
dc.contributor.authorCho, Kangwooko
dc.contributor.authorLee, Changhako
dc.contributor.authorPark, Hyun-Meeko
dc.contributor.authorHong, Seok Wonko
dc.date.available2018-05-24T00:41:04Z-
dc.date.created2018-05-21ko
dc.date.issued201808ko
dc.identifier.citationSCIENCE OF THE TOTAL ENVIRONMENT, v.633, no., pp.352 - 359ko
dc.identifier.issn0048-9697ko
dc.identifier.urihttp://scholarworks.unist.ac.kr/handle/201301/24136-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0048969718309409?via%3Dihubko
dc.description.abstractRanitidine (RNT) has been an important tertiary amine precursor of N-nitrosodimethylamine (NDMA) in chlorine-based water treatment, due to reaction with monochloramine (NH2Cl) with exceptionally high molar yields up to 90%. This study examined the effects of nitrite ions (NO2 −) on the kinetics of NDMA formation during the chloramination of RNT under variable concentrations of dissolved oxygen (DO, 0.7–7.5 mg/L), RNT (5–30 μM), NH2Cl (5–20 mM), NO2 − or NO3 − (0–2 mM) and pH (5.6–8.6). In the absence of the NO2 −, the ultimate molar yield of NDMA after 6 h of reaction was primarily influenced by [DO] and pH, while marginally affected by initial [RNT] and [NH2Cl]. A kinetic model, prepared in accordance with the reaction sequence of NDMA formation, suggested that the rate determining step was accelerated with increasing [NH2Cl]0, [DO], and pH. A Kinetic study together with ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometer (UPLC-Q-TOF MS) and gas chromatography (GC)/TOF MS analyses in parallel demonstrated that the nitrite ion inhibited the nucleophilic substitution of the terminal amine on NH2Cl, and reduced the pseudo-steady state concentration of N-peroxyl radicals, significantly decreasing the ultimate yields of NDMA.ko
dc.languageENGko
dc.publisherELSEVIER SCIENCE BVko
dc.subjectN-nitrosodimethylamineko
dc.subjectRanitidineko
dc.subjectNitrite ionko
dc.subjectChloraminationko
dc.subjectKineticsko
dc.subjectReaction pathwayko
dc.titleNitrite ion mitigates the formation of N-nitrosodimethylamine (NDMA) during chloramination of ranitidineko
dc.typeARTICLEko
dc.identifier.pid1046null
dc.identifier.rimsid30330ko
dc.identifier.scopusid2-s2.0-85044525205ko
dc.identifier.wosid000432475300035ko
dc.type.rimsAko
dc.identifier.doihttp://dx.doi.org/10.1016/j.scitotenv.2018.03.181ko
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