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DC Field | Value | Language |
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dc.citation.endPage | 1722 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1716 | - |
dc.citation.title | ACS BIOMATERIALS SCIENCE & ENGINEERING | - |
dc.citation.volume | 4 | - |
dc.contributor.author | Palanikumar, L. | - |
dc.contributor.author | Kim, Jimin | - |
dc.contributor.author | Oh, Jun Yong | - |
dc.contributor.author | Choi, Huyeon | - |
dc.contributor.author | Park, Myoung-Hwan | - |
dc.contributor.author | Kim, Chaekyu | - |
dc.contributor.author | Ryu, Ja-Hyoung | - |
dc.date.accessioned | 2023-12-21T20:46:22Z | - |
dc.date.available | 2023-12-21T20:46:22Z | - |
dc.date.created | 2018-04-24 | - |
dc.date.issued | 2018-05 | - |
dc.description.abstract | Systemic administration of mesoporous silica nanoparticles (MSNs) in biomedical applications has recently been questioned because of poor degradability, which is necessary for the successful development of new drug-delivery systems. Herein, we report the development of colloidal-state-degradable MSNs functionalized with versatile polymer-gatekeepers with a cancer-cell-targeted moiety. The polymer MSNs (PMSNs) were designed with disulfide cross-linking enabling safe encapsulation until cargos are delivered to target cancer cells. Selective targeting was achieved by decoration of CD44-receptor-targeting ligands, hyaluronic acid (HA), with HA-PMSNs. The selective cellular uptake mechanism of the fabricated targeted nanocarrier into CD44-overexpressed cancer cells was demonstrated through the clathrin- and macropinocytosis-mediated pathways. Upon internalization into cancer cells, doxorubicin loaded into the HA-PMSNs can be released by degradation of the polymer shells in the reducing intracellular microenvironment that consequentially induces cell death and further degradation of the MSNs. This study offers a simple technique to fabricate a versatile drug carrier with a high drug loading capacity. | - |
dc.identifier.bibliographicCitation | ACS BIOMATERIALS SCIENCE & ENGINEERING, v.4, no.5, pp.1716 - 1722 | - |
dc.identifier.doi | 10.1021/acsbiomaterials.8b00218 | - |
dc.identifier.issn | 2373-9878 | - |
dc.identifier.scopusid | 2-s2.0-85046963419 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24035 | - |
dc.identifier.url | https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.8b00218 | - |
dc.identifier.wosid | 000432476200025 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Hyaluronic Acid-Modified Polymeric Gatekeepers on Biodegradable Mesoporous Silica Nanoparticles for Targeted Cancer Therapy | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | degradable mesoporous silica | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | CD-44 overexpression | - |
dc.subject.keywordAuthor | redox responsive | - |
dc.subject.keywordAuthor | high loading capacity | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | CARGO RELEASE | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | PH | - |
dc.subject.keywordPlus | NANOCONTAINERS | - |
dc.subject.keywordPlus | HYDROXYAPATITE | - |
dc.subject.keywordPlus | PLATFORM | - |
dc.subject.keywordPlus | CELLS | - |
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