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Kwon, Tae-Hyuk
Energy Recognition
Research Interests
  • Energy transfer, organic solar cells, supercapacitor, ultrasonic spray chemistry, dithienothiophene, iridium complexes, phosphorescent bioapplications

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Reduction‐Triggered Self‐Cross‐Linked Hyperbranched Polyglycerol Nanogels for Intracellular Delivery of Drugs and Proteins

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dc.contributor.authorPark, Haereeko
dc.contributor.authorChoi, Yeongkyuko
dc.contributor.authorJeena, M. T.ko
dc.contributor.authorAhn, Eungjinko
dc.contributor.authorChoi, Yuriko
dc.contributor.authorKang, Myeong-Gyunko
dc.contributor.authorLee, Chae Gyuko
dc.contributor.authorKwon, Tae-Hyukko
dc.contributor.authorRhee, Hyun-Wooko
dc.contributor.authorRyu, Ja-Hyoungko
dc.contributor.authorKim, Byeong-Suko
dc.date.available2018-05-04T00:49:12Z-
dc.date.created2018-04-24ko
dc.date.issued201804ko
dc.identifier.citationMACROMOLECULAR BIOSCIENCE, v.18, no.4, pp.1700356 -ko
dc.identifier.issn1616-5187ko
dc.identifier.urihttp://scholarworks.unist.ac.kr/handle/201301/24024-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/mabi.201700356ko
dc.description.abstractOwing to the unique advantages of combining the characteristics of hydrogels and nanoparticles, nanogels are actively investigated as a promising platform for advanced biomedical applications. In this work, a self‐cross‐linked hyperbranched polyglycerol nanogel is synthesized using the thiol–disulfide exchange reaction based on a novel disulfide‐containing polymer. A series of structural analyses confirm the tunable size and cross‐linking density depending on the type of polymer (homo‐ or copolymer) and the amount of reducing agent, dithiothreitol, used in the preparation of the nanogels. The nanogels retain not only small molecular therapeutics irrespective of hydrophilic and hydrophobic nature but also large enzymes such as β‐galactosidase by exploiting the self‐cross‐linking chemistry. Their superior biocompatibility together with the controllable release of active therapeutic agents suggests the applicability of nanogels in smart drug delivery systems.ko
dc.languageENGko
dc.publisherWILEY-V C H VERLAG GMBHko
dc.subjectbiocompatibilityko
dc.subjectcoencapsulationko
dc.subjectnanogelko
dc.subjectpolyglycerolko
dc.subjectredox-responsiveko
dc.titleReduction‐Triggered Self‐Cross‐Linked Hyperbranched Polyglycerol Nanogels for Intracellular Delivery of Drugs and Proteinsko
dc.typeARTICLEko
dc.identifier.pid1278null
dc.identifier.pid1261null
dc.identifier.pid1298null
dc.identifier.pid1052null
dc.identifier.rimsid30189ko
dc.identifier.scopusid2-s2.0-85045521958ko
dc.identifier.wosid000430395900005ko
dc.type.rimsAko
dc.identifier.doihttp://dx.doi.org/10.1002/mabi.201700356ko
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