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Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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Optical properties of acute kidney injury measured by quantitative phase imaging

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Title
Optical properties of acute kidney injury measured by quantitative phase imaging
Author
Ban, SungbeaMin, EunjungBaek, SongyeeKwon, Hyug MooPopescu, GabrielJung, Woonggyu
Issue Date
201803
Publisher
OPTICAL SOC AMER
Citation
BIOMEDICAL OPTICS EXPRESS, v.9, no.3, pp.921 - 932
Abstract
The diagnosis of acute kidney disease (AKI) has been examined mainly by histology, immunohistochemistry and western blot. Though these approaches are widely accepted in the field, it has an inherent limitation due to the lack of high-throughput and quantitative information. For a better understanding of prognosis in AKI, we present a new approach using quantitative phase imaging combined with a wide-field scanning platform. Through the phase-delay information from the tissue, we were able to predict a stage of AKI based on various optical properties such as light scattering coefficient and anisotropy. These optical parameters quantify the deterioration process of the AKI model of tissue. Our device would be a very useful tool when it is required to deliver fast feedback of tissue pathology or when diseases are related to mechanical properties such as fibrosis.
URI
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DOI
http://dx.doi.org/10.1364/BOE.9.000921
ISSN
2156-7085
Appears in Collections:
SLS_Journal Papers
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