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Seo, Jeong Kon
UNIST Central Research Facilities (UCRF)
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  • Discovery of novel bioactive peptides

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Trib2 regulates the pluripotency of embryonic stem cells and enhances reprogramming efficiency

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dc.contributor.authorDo, Eun Kyoungko
dc.contributor.authorPark, Jae Kyungko
dc.contributor.authorCheon, Hyo Cheonko
dc.contributor.authorKwon, Yang Wooko
dc.contributor.authorHeo, Soon Chulko
dc.contributor.authorChoi, Een Jungko
dc.contributor.authorSeo, Jeong Konko
dc.contributor.authorJang, Il Hoko
dc.contributor.authorLee, Sang Chulko
dc.contributor.authorKim, Jae Hoko
dc.date.available2018-03-02T00:29:56Z-
dc.date.created2018-02-23ko
dc.date.issued201711ko
dc.identifier.citationEXPERIMENTAL AND MOLECULAR MEDICINE, v.49, no., pp.e401 -ko
dc.identifier.issn1226-3613ko
dc.identifier.urihttp://scholarworks.unist.ac.kr/handle/201301/23703-
dc.identifier.urihttps://www.nature.com/articles/emm2017191ko
dc.description.abstractEmbryonic stem (ES) cells are pluripotent cells characterized by self-renewability and differentiation potential. Induced pluripotent stem (iPS) cells are ES cell-equivalent cells derived from somatic cells by the introduction of core reprogramming factors. ES and iPS cells are important sources for understanding basic biology and for generating therapeutic cells for clinical applications. Tribbles homolog 2 (Trib2) functions as a scaffold in signaling pathways. However, the relevance of Trib2 to the pluripotency of ES and iPS cells is unknown. In the present study, we elucidated the importance of Trib2 in maintaining pluripotency in mouse ES cells and in generating iPS cells from somatic cells through the reprogramming process. Trib2 expression decreased as ES cells differentiated, and Trib2 knockdown in ES cells changed their colony morphology while reducing the activity of alkaline phosphatase and the expression of the pluripotency marker genes Oct4, Sox2, Nanog and Klf4. Trib2 directly interacted with Oct4 and elevated Oct4 promoter activity. During the generation of iPS cells, Trib2 knockdown decreased the reprogramming efficiency of mouse embryonic fibroblasts, whereas Trib2 overexpression significantly increased their reprogramming efficiency. In summary, our results suggest that Trib2 is important for maintaining self-renewal in ES cells and for pluripotency induction during the reprogramming process.ko
dc.languageENGko
dc.publisherNATURE PUBLISHING GROUPko
dc.titleTrib2 regulates the pluripotency of embryonic stem cells and enhances reprogramming efficiencyko
dc.typeARTICLEko
dc.identifier.pid1131null
dc.identifier.rimsid29838ko
dc.identifier.wosid000427482600005ko
dc.type.rimsAko
dc.identifier.doihttp://dx.doi.org/10.1038/emm.2017.191ko
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