File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

조윤경

Cho, Yoon-Kyoung
FRUITS Lab.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Cell migration in microengineered tumor environments

Author(s)
Um, EujinOh, Jung MinGranick, SteveCho, Yoon-Kyoung
Issued Date
2017-12
DOI
10.1039/c7lc00555e
URI
https://scholarworks.unist.ac.kr/handle/201301/23226
Fulltext
http://pubs.rsc.org/en/Content/ArticleLanding/2017/LC/C7LC00555E#!divAbstract
Citation
LAB ON A CHIP, v.17, no.24, pp.4171 - 4185
Abstract
Recent advances in microengineered cell migration platforms are discussed critically with a focus on how cell migration is influenced by engineered tumor microenvironments, the medical relevance being to understand how tumor microenvironments may promote or suppress the progression of cancer. We first introduce key findings in cancer cell migration under the influence of the physical environment, which is systematically controlled by microengineering technology, followed by multi-cues of physico-chemical factors, which represent the complexity of the tumor environment. Recognizing that cancer cells constantly communicate not only with each other but also with tumor-associated cells such as vascular, fibroblast, and immune cells, and also with non-cellular components, it follows that cell motility in tumor microenvironments, especially metastasis via the invasion of cancer cells into the extracellular matrix and other tissues, is closely related to the malignancy of cancer-related mortality. Medical relevance of forefront research realized in microfabricated devices, such as single cell sorting based on the analysis of cell migration behavior, may assist personalized theragnostics based on the cell migration phenotype. Furthermore, we urge development of theory and numerical understanding of single or collective cell migration in microengineered platforms to gain new insights in cancer metastasis and in therapeutic strategies.
Publisher
ROYAL SOC CHEMISTRY
ISSN
1473-0197
Keyword
MICROFLUIDIC PLATFORMSHEAR-STRESSINTERSTITIAL FLOWMATRIX STIFFNESSCOCULTURE SYSTEMBREAST-CANCERIMMUNE CELLSEPITHELIAL-MESENCHYMAL TRANSITIONCANCER-ASSOCIATED FIBROBLASTSENDOTHELIAL BARRIER FUNCTION

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.