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Author

Kang, Hyun-Wook
3D Biofabrication Lab (3BL)
Research Interests
  • 3D Bioprinting, tissue engineering and regenerative medicine, Body-on-a-chip

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Multi-tissue interactions in an integrated three-tissue organ-on-a chip platform

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dc.contributor.authorSkardal, Aleksander null
dc.contributor.authorMurphy, Sean V.null
dc.contributor.authorDevarasetty, Maheshnull
dc.contributor.authorMead, Ivynull
dc.contributor.authorKang, Hyun-Wooknull
dc.contributor.authorSeol, Young-Joonnull
dc.contributor.authorZhang, Yu Shrikenull
dc.contributor.authorShin, Su-Ryonnull
dc.contributor.authorZhao, Liangnull
dc.contributor.authorAleman, Julionull
dc.contributor.authorHall,Adam R.null
dc.contributor.authorShupe, Thomas Dnull
dc.contributor.authorKleensang, Andrenull
dc.contributor.authorDokmeci, Mehmet R.null
dc.contributor.authorLee, Sang Jinnull
dc.contributor.authorJackson, John D.null
dc.contributor.authorYoo, James J.null
dc.contributor.authorHartung, Thomasnull
dc.contributor.authorKhademhosseini, Alinull
dc.contributor.authorSoker, Shaynull
dc.contributor.authorBishop, Colin E.null
dc.contributor.authorAtala, Anthonynull
dc.date.accessioned2018-01-11T11:35:39Z-
dc.date.available2018-01-11T11:35:39Z-
dc.date.created2018-01-05null
dc.date.issued201708null
dc.identifier.citationSCIENTIFIC REPORTS, v.7, no., pp.8837 - null
dc.identifier.issn2045-2322null
dc.identifier.urihttps://www.nature.com/articles/s41598-017-08879-xnull
dc.identifier.urihttp://scholarworks.unist.ac.kr/handle/201301/23198-
dc.description.abstractMany drugs have progressed through preclinical and clinical trials and have been available – for years in some cases – before being recalled by the FDA for unanticipated toxicity in humans. One reason for such poor translation from drug candidate to successful use is a lack of model systems that accurately recapitulate normal tissue function of human organs and their response to drug compounds. Moreover, tissues in the body do not exist in isolation, but reside in a highly integrated and dynamically interactive environment, in which actions in one tissue can affect other downstream tissues. Few engineered model systems, including the growing variety of organoid and organ-on-a-chip platforms, have so far reflected the interactive nature of the human body. To address this challenge, we have developed an assortment of bioengineered tissue organoids and tissue constructs that are integrated in a closed circulatory perfusion system, facilitating inter-organ responses. We describe a three-tissue organ-on-a-chip system, comprised of liver, heart, and lung, and highlight examples of inter-organ responses to drug administration. We observe drug responses that depend on inter-tissue interaction, illustrating the value of multiple tissue integration for in vitro study of both the efficacy of and side effects associated with candidate drugs.null
dc.languageENGnull
dc.publisherNATURE PUBLISHING GROUPnull
dc.titleMulti-tissue interactions in an integrated three-tissue organ-on-a chip platformnull
dc.typeARTICLEnull
dc.identifier.pid2461null
dc.identifier.rimsid29587null
dc.identifier.scopusid2-s2.0-85027888827null
dc.identifier.wosid000407980000091null
dc.type.rimsAnull
dc.identifier.doi10.1038/s41598-017-08879-xnull
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