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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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The Power of the Ring: pH-Responsive Hydrophobic Epoxide Monomer for Superior Micelle Stability

DC FieldValueLanguage
dc.contributor.authorSong, Jaeeunko
dc.contributor.authorPalanikumar, Lko
dc.contributor.authorChoi, Yeongkyuko
dc.contributor.authorKim, Inhyeko
dc.contributor.authorHeo, Tae-youngko
dc.contributor.authorAhn, Eungjinko
dc.contributor.authorChoi, Soo-Hyungko
dc.contributor.authorLee, Eunjiko
dc.contributor.authorShibasaki, Yujiko
dc.contributor.authorRyu, Ja-Hyoungko
dc.contributor.authorKim, Byeong-Suko
dc.date.available2018-01-11T11:32:55Z-
dc.date.created2018-01-05ko
dc.date.issued201712ko
dc.identifier.citationPOLYMER CHEMISTRY, v.8, no.46, pp.7119 - 7132ko
dc.identifier.issn1759-9954ko
dc.identifier.urihttp://scholarworks.unist.ac.kr/handle/201301/23190-
dc.identifier.urihttp://pubs.rsc.org/en/Content/ArticleLanding/2017/PY/C7PY01613A#!divAbstractko
dc.description.abstractDespite the growing interest in amphiphilic block copolymers for their application in micelles as ideal drug delivery carriers, there remain some challenges related to biocompatibility, stability, degradability, and loading efficiency of the micelles. Herein, we report a novel hydrophobic, pH-responsive epoxide monomer, tetrahydropyranyl glycidyl ether (TGE). Anionic ring-opening polymerization affords the controlled synthesis of a series of its homopolymers (PTGE) and amphiphilic polymers, poly(ethylene glycol)-block-poly(tetrahydropyranyl glycidyl ether) (PEG-b-PTGE). Interestingly, these block copolymers with cyclic TGE moieties showed superior stability in biological media, high loading capacity, tunable release, and controllable degradation compared to the block copolymers with its acyclic analogue, 1-ethoxyethyl glycidyl ether (EEGE), widely employed in polyether, which satisfy all the required design principles and address the challenges in drug delivery systems. The superior biocompatibility coupled with the high stability of the novel functional epoxide monomer is anticipated to lead to the development of a versatile platform for smart drug delivery systems.ko
dc.languageENGko
dc.publisherROYAL SOC CHEMISTRYko
dc.titleThe Power of the Ring: pH-Responsive Hydrophobic Epoxide Monomer for Superior Micelle Stabilityko
dc.typeARTICLEko
dc.identifier.pid1298null
dc.identifier.pid1052null
dc.identifier.rimsid29588ko
dc.type.rimsAko
dc.identifier.doihttp://dx.doi.org/10.1039/C7PY01613Ako
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