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Ryu, Ja-Hyoung
Supramolecular Nanomaterials Lab.
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dc.citation.endPage 7132 -
dc.citation.number 46 -
dc.citation.startPage 7119 -
dc.citation.title POLYMER CHEMISTRY -
dc.citation.volume 8 -
dc.contributor.author Song, Jaeeun -
dc.contributor.author Palanikumar, L -
dc.contributor.author Choi, Yeongkyu -
dc.contributor.author Kim, Inhye -
dc.contributor.author Heo, Tae-young -
dc.contributor.author Ahn, Eungjin -
dc.contributor.author Choi, Soo-Hyung -
dc.contributor.author Lee, Eunji -
dc.contributor.author Shibasaki, Yuji -
dc.contributor.author Ryu, Ja-Hyoung -
dc.contributor.author Kim, Byeong-Su -
dc.date.accessioned 2023-12-21T21:19:54Z -
dc.date.available 2023-12-21T21:19:54Z -
dc.date.created 2018-01-05 -
dc.date.issued 2017-12 -
dc.description.abstract Despite the growing interest in amphiphilic block copolymers for their application in micelles as ideal drug delivery carriers, there remain some challenges related to biocompatibility, stability, degradability, and loading efficiency of the micelles. Herein, we report a novel hydrophobic, pH-responsive epoxide monomer, tetrahydropyranyl glycidyl ether (TGE). Anionic ring-opening polymerization affords the controlled synthesis of a series of its homopolymers (PTGE) and amphiphilic polymers, poly(ethylene glycol)-block-poly(tetrahydropyranyl glycidyl ether) (PEG-b-PTGE). Interestingly, these block copolymers with cyclic TGE moieties showed superior stability in biological media, high loading capacity, tunable release, and controllable degradation compared to the block copolymers with its acyclic analogue, 1-ethoxyethyl glycidyl ether (EEGE), widely employed in polyether, which satisfy all the required design principles and address the challenges in drug delivery systems. The superior biocompatibility coupled with the high stability of the novel functional epoxide monomer is anticipated to lead to the development of a versatile platform for smart drug delivery systems. -
dc.identifier.bibliographicCitation POLYMER CHEMISTRY, v.8, no.46, pp.7119 - 7132 -
dc.identifier.doi 10.1039/C7PY01613A -
dc.identifier.issn 1759-9954 -
dc.identifier.scopusid 2-s2.0-85036474414 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/23190 -
dc.identifier.url http://pubs.rsc.org/en/Content/ArticleLanding/2017/PY/C7PY01613A#!divAbstract -
dc.identifier.wosid 000416431800005 -
dc.language 영어 -
dc.publisher ROYAL SOC CHEMISTRY -
dc.title The Power of the Ring: pH-Responsive Hydrophobic Epoxide Monomer for Superior Micelle Stability -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Polymer Science -
dc.relation.journalResearchArea Polymer Science -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus BLOCK-COPOLYMER NANOPARTICLES -
dc.subject.keywordPlus POLYMERIC MICELLES -
dc.subject.keywordPlus OPENING POLYMERIZATION -
dc.subject.keywordPlus GLYCIDYL ETHER -
dc.subject.keywordPlus DRUG-DELIVERY -
dc.subject.keywordPlus IN-VIVO -
dc.subject.keywordPlus HYPERBRANCHED POLYGLYCEROLS -
dc.subject.keywordPlus MULTIFUNCTIONAL POLYETHER -
dc.subject.keywordPlus POLY(ETHYLENE GLYCOL) -
dc.subject.keywordPlus CORE CRYSTALLINITY -

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