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Cho, Yoon-Kyoung
Integrated Nano-Biotech Lab (INBL)
Research Interests
  • Microfluidics, Lab-on-a-chip, personalized biomedical diagnostics, nanobioengineering

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Centrifugal microfluidic system for a fully automated N-fold serial dilution

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Title
Centrifugal microfluidic system for a fully automated N-fold serial dilution
Author
Kim, Tae-HyeongKim, Chi-JuKim, YubinCho, Yoon-Kyoung
Keywords
Centrifugal microfluidics; Serial dilution; Valves; Metering; Lab-on-a-disc
Issue Date
201803
Publisher
ELSEVIER SCIENCE SA
Citation
SENSORS AND ACTUATORS B-CHEMICAL, v.256, no., pp.310 - 317
Abstract
We present an innovative tool for a fully automated N-fold serial dilution with a choice of N = 2, 5, 10 on a centrifugal microfluidic device. Individually addressable, reversible diaphragm valves are integrated on the disc for the automatic control of the fluidic transfer. Two metering zones are designed with three microfluidic chambers with the volume of 1 μL, 3 μL and 5 μL to meter the samples or the dilution buffer. The pre-programmed operation of the valves enabled the automatic serial dilution with the choice of the dilution factor of 2, 5, or 10 at each dilution steps. The samples prepared on the disc with various serial dilution factor showed excellent accuracy (R2 > 0.970). The automatic serial dilution disc could be an essential tool in the laboratory to replace the time-consuming and iterative pipetting especially when the sample volume is limited.
URI
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DOI
http://dx.doi.org/10.1016/j.snb.2017.10.096
ISSN
0925-4005
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