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DC Field | Value | Language |
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dc.citation.endPage | 3669 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 3661 | - |
dc.citation.title | LAB ON A CHIP | - |
dc.citation.volume | 15 | - |
dc.contributor.author | Zhang, Yu Shrike | - |
dc.contributor.author | Ribas, Joao | - |
dc.contributor.author | Nadhman, Akhtar | - |
dc.contributor.author | Aleman, Julio | - |
dc.contributor.author | Selimovic, Seila | - |
dc.contributor.author | Lesher-Perez, Sasha Cai | - |
dc.contributor.author | Wang, Ting | - |
dc.contributor.author | Manoharan, Vijayan | - |
dc.contributor.author | Shin, Su-Ryon | - |
dc.contributor.author | Damilano, Alessia | - |
dc.contributor.author | Annabi, Nasim | - |
dc.contributor.author | Dokmeci, Mehmet Remzi | - |
dc.contributor.author | Takayama, Shuichi | - |
dc.contributor.author | Khademhosseini, Ali | - |
dc.date.accessioned | 2023-12-22T00:42:29Z | - |
dc.date.available | 2023-12-22T00:42:29Z | - |
dc.date.created | 2017-09-13 | - |
dc.date.issued | 2015-09 | - |
dc.description.abstract | We have designed and fabricated a miniature microscope from off-the-shelf components and a webcam, with built-in fluorescence capability for biomedical applications. The mini-microscope was able to detect both biochemical parameters, such as cell/tissue viability (e.g. live/dead assay), and biophysical properties of the microenvironment such as oxygen levels in microfabricated tissues based on an oxygen-sensitive fluorescent dye. This mini-microscope has adjustable magnifications from 8-60x, achieves a resolution as high as < 2 mu m, and possesses a long working distance of 4.5 mm (at a magnification of 8x). The mini-microscope was able to chronologically monitor cell migration and analyze beating of microfluidic liver and cardiac bioreactors in real time, respectively. The mini-microscope system is cheap, and its modularity allows convenient integration with a wide variety of pre-existing platforms including, but not limited to, cell culture plates, microfluidic devices, and organs-on-a-chip systems. Therefore, we envision its widespread application in cell biology, tissue engineering, biosensing, microfluidics, and organs-on-chips, which can potentially replace conventional bench-top microscopy where long-term in situ and large-scale imaging/analysis is required. | - |
dc.identifier.bibliographicCitation | LAB ON A CHIP, v.15, no.18, pp.3661 - 3669 | - |
dc.identifier.doi | 10.1039/c5lc00666j | - |
dc.identifier.issn | 1473-0197 | - |
dc.identifier.scopusid | 2-s2.0-84940033699 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/22689 | - |
dc.identifier.url | http://pubs.rsc.org/en/Content/ArticleLanding/2015/LC/C5LC00666J#!divAbstract | - |
dc.identifier.wosid | 000360114300004 | - |
dc.language | 영어 | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | A cost-effective fluorescence mini-microscope for biomedical applications | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods; Chemistry, Multidisciplinary; Chemistry, Analytical; Nanoscience & Nanotechnology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Chemistry; Science & Technology - Other Topics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ON-A-CHIP | - |
dc.subject.keywordPlus | DRUG DISCOVERY | - |
dc.subject.keywordPlus | CELL-CULTURE | - |
dc.subject.keywordPlus | HUMAN LIVER | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | BIOREACTORS | - |
dc.subject.keywordPlus | CHALLENGES | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordPlus | CARDIOTOXICITY | - |
dc.subject.keywordPlus | RESOLUTION | - |
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