There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 57 | - |
dc.citation.startPage | 43 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 102 | - |
dc.contributor.author | Islam, Mohammad Ariful | - |
dc.contributor.author | Kim, Sanghwa | - |
dc.contributor.author | Firdous, Jannatul | - |
dc.contributor.author | Lee, Ah-Young | - |
dc.contributor.author | Hong, Seong-Ho | - |
dc.contributor.author | Seo, Min Kyeong | - |
dc.contributor.author | Park, Tae-Eun | - |
dc.contributor.author | Yun, Cheol-Heui | - |
dc.contributor.author | Choi, Yun-Jaie | - |
dc.contributor.author | Chae, Chanhee | - |
dc.contributor.author | Cho, Chong-Su | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2023-12-21T23:12:21Z | - |
dc.date.available | 2023-12-21T23:12:21Z | - |
dc.date.created | 2017-09-01 | - |
dc.date.issued | 2016-09 | - |
dc.description.abstract | Aside from kidney transplantation a procedure which is exceedingly dependent on donor-match and availability leading to excessive costs there are currently no permanent treatments available which reverse kidney injury and failure. However, kidney-specific targeted gene therapy has outstanding potential to treat kidney-related dysfunction. Herein we report a novel kidney-specific targeted gene delivery system developed through the conjugation of chitobionic acid (CBA) to a polysorbitol gene transporter (PSGT) synthesized from sorbitol diacrylate and low molecular weight polyethylenimine (PEI) carrying hepatocyte growth factor (HGF) gene to alleviate unilateral ureteral obstruction (UUO) in rats. CBA-PSGT performed exceptionally well for targeted delivery of HGF to kidney tissues compared to its non-targeted counterparts (P < 0.001) after systemic tail-vein injection and significantly reduced the UUO symptoms, returning the UUO rats to a normal health status. The kidney-targeted CBA-PSGT-delivered HGF also strikingly reduced various pathologic and molecular markers in vivo such as the level of collagens (type I and II), blood urea nitrogen (BUN), creatinine, and the expressions of ICAM-1, TIMP-1 and alpha-S1VIA which play a critical role in obstructive kidney functions. Therefore, CBA-PSGT should be further investigated because of its potential to alleviate UUO and kidney-related diseases using high affinity kidney targeting. | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.102, pp.43 - 57 | - |
dc.identifier.doi | 10.1016/j.biomaterials.2016.06.013 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.scopusid | 2-s2.0-84975499806 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/22629 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0142961216302678?via%3Dihub | - |
dc.identifier.wosid | 000380625700004 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | A high affinity kidney targeting by chitobionic acid-conjugated polysorbitol gene transporter alleviates unilateral ureteral obstruction in rats | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.