There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 12124 | - |
dc.citation.number | 35 | - |
dc.citation.startPage | 12121 | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 139 | - |
dc.contributor.author | Kim, Woo Gyum | - |
dc.contributor.author | Kang, Mi Eun | - |
dc.contributor.author | Lee, Jae Bin | - |
dc.contributor.author | Jeon, Min Ho | - |
dc.contributor.author | Lee, Sungmin | - |
dc.contributor.author | Lee, Jungha | - |
dc.contributor.author | Choi, Bongseo | - |
dc.contributor.author | Cal, Pedro M. S. D. | - |
dc.contributor.author | Kang, Sebyung | - |
dc.contributor.author | Kee, Jung-Min | - |
dc.contributor.author | Bernardes, Gonçalo J.L. | - |
dc.contributor.author | Rohde, Jan-Uwe | - |
dc.contributor.author | Choe, Wonyoung | - |
dc.contributor.author | Hong, Sung You | - |
dc.date.accessioned | 2023-12-21T21:46:58Z | - |
dc.date.available | 2023-12-21T21:46:58Z | - |
dc.date.created | 2017-08-17 | - |
dc.date.issued | 2017-09 | - |
dc.description.abstract | Transition-metal-catalyzed or metal-free azide-alkyne cycloadditions are versatile and indispensable synthetic methods to access 1,4- or 1,5-disubstituted 1,2,3-triazoles. Although the copper-catalyzed cycloaddition to access 1,4-disubstituted products has been successfully applied to biomolecular reaction systems, the azide-alkyne cycloaddition to access the complementary 1,5-regioisomers under aqueous and ambient conditions remains a formidable challenge due to limited substrate scope or moisture-/air-sensitive catalysts. Herein, we report a general synthetic method to access 1,5-disubstituted 1,2,3-triazoles using a Cp2Ni/Xantphos catalytic system. The reaction proceeds both in water and organic solvents at room temperature. This protocol is operationally simple and scalable with a broad substrate scope including both aliphatic and aromatic substrates. Moreover, triazoles attached with carbohydrates or amino acids are readily prepared via this nickel-catalyzed azide-alkyne cycloaddition. | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.139, no.35, pp.12121 - 12124 | - |
dc.identifier.doi | 10.1021/jacs.7b06338 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.scopusid | 2-s2.0-85028929919 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/22474 | - |
dc.identifier.url | http://pubs.acs.org/doi/10.1021/jacs.7b06338 | - |
dc.identifier.wosid | 000410255600005 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Nickel-Catalyzed Azide-Alkyne Cycloaddition to Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | CLICK CHEMISTRY | - |
dc.subject.keywordPlus | 1,3-DIPOLAR CYCLOADDITIONS | - |
dc.subject.keywordPlus | TERMINAL ALKYNES | - |
dc.subject.keywordPlus | SOLID-PHASE | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | BIOCONJUGATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | CYCLIZATIONS | - |
dc.subject.keywordPlus | COUPLINGS | - |
dc.subject.keywordPlus | LIGATION | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.