BROWSE

Related Researcher

Author

Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

ITEM VIEW & DOWNLOAD

Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression

Cited 1 times inthomson ciCited 0 times inthomson ci
Title
Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression
Author
Poli, AlessandroFiume, RobertaBaldanzi, GianlucaCapello, DanielaRatti, StefanoGesi, MarcoManzoli, LuciaGraziani, AndreaSuh, Pann-GhillCocco, LucioFollo, Matilde Y.
Issue Date
201709
Publisher
WILEY
Citation
JOURNAL OF CELLULAR PHYSIOLOGY, v.232, no.9, pp.2550 - 2557
Abstract
Phosphatidylinositol (PI) signaling is an essential regulator of cellmotility and proliferation. Aportion of PI metabolism and signaling takes place in the nuclear compartment of eukaryotic cells, where an array of kinases and phosphatases localize and modulate PI. Among these, Diacylglycerol Kinases (DGKs) are a class of phosphotransferases that phosphorylate diacylglycerol and induce the synthesis of phosphatidic acid. Nuclear DGKalpha modulates cell cycle progression, and its activity or expression can lead to changes in the phosphorylated status of the Retinoblastoma protein, thus, impairing G1/S transition and, subsequently, inducing cell cycle arrest, which is often uncoupled with apoptosis or autophagy induction. Here we report for the first time not only that the DGKalpha isoform is highly expressed in the nuclei of human erythroleukemia cell line K562, but also that its nuclear activity drives K562 cells through the G1/S transition during cell cycle progression.
URI
Go to Link
DOI
http://dx.doi.org/10.1002/jcp.25642
ISSN
0021-9541
Appears in Collections:
SLS_Journal Papers

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU